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Preliminary support for gender differences in response to fluoxetine for generalized anxiety disorder
- Source :
- Depression and anxiety. 23(6)
- Publication Year :
- 2006
-
Abstract
- Women have a higher prevalence of generalized anxiety disorder (GAD) than do men, but few studies have assessed gender differences in response to pharmacotherapy. In this study we examined gender as a correlate of response to 6 weeks of open, prospective fluoxetine treatment in 23 men and 22 women with a primary diagnosis of GAD. There was no difference by gender in age or prevalence of mood and anxiety comorbidity; however, GAD onset occurred at a significantly younger age in women compared with men. Despite a lack of difference in baseline severity measures, women had a significantly poorer response to fluoxetine as measured by both the Hamilton Anxiety Rating Scale (HAM-A) and Clinician Global Impression-Severity Scale (CGI-S). In multivariate analyses, there was a significant interaction between age of onset and gender: men with younger age of onset and women with older age of onset exhibited poorer response on the HAM-A. These data, though limited in sample size and by the post hoc nature of our analyses, offer preliminary support that women with GAD, particularly those with a later age of onset, may have a poorer response to the selective serotonin reuptake inhibitor (SSRI) fluoxetine. Larger placebo-controlled trials are needed to more definitively examine gender and treatment response in anxiety disorders.
- Subjects :
- Adult
Male
medicine.medical_specialty
Generalized anxiety disorder
Hamilton Anxiety Rating Scale
Serotonin reuptake inhibitor
Comorbidity
Sex Factors
Fluoxetine
Surveys and Questionnaires
medicine
Prevalence
Humans
Prospective Studies
Age of Onset
Psychiatry
Depression
medicine.disease
Anxiety Disorders
Psychiatry and Mental health
Clinical Psychology
Mood
Treatment Outcome
Anxiety
Female
Age of onset
medicine.symptom
Dysthymic Disorder
Psychology
Selective Serotonin Reuptake Inhibitors
Clinical psychology
medicine.drug
Subjects
Details
- ISSN :
- 10914269
- Volume :
- 23
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Depression and anxiety
- Accession number :
- edsair.doi.dedup.....f430f4adc804b427efd826cb48e3a4f2