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Outbreak of Shiga toxin-producing Escherichia coli O157:H7 linked to raw drinking milk resolved by rapid application of advanced pathogen characterisation methods, England, August to October 2017
- Source :
- Eurosurveillance
- Publication Year :
- 2019
- Publisher :
- European Centre for Disease Prevention and Control (ECDC), 2019.
-
Abstract
- An outbreak of Shiga toxin-producing Escherichia coli (STEC) O157:H7 occurred on the Isle of Wight between August and October 2017. Of the seven cases linked to the outbreak, five were identified through the statutory notification process and two were identified through national surveillance of whole genome sequencing data. Enhanced surveillance questionnaires established a common link to a farm, and link to the likely food vehicle, raw drinking milk (RDM). Microbiological investigations, including PCR, identified the presence of STEC O157:H7 in samples of RDM. Analysis of core genome single nucleotide polymorphism (SNP) data of STEC O157:H7 from human stool specimens, animal faecal samples and RDM demonstrated a one SNP difference between isolates, and therefore close genetic relatedness. Control measures that were put in place included suspension of sales and recall of RDM, as well as restrictions on public access to parts of the farm. Successful integration of traditional epidemiological surveillance and advanced laboratory methods for the detection and characterisation of STEC O157:H7 from human, animal and environmental samples enabled prompt identification of the outbreak vehicle and provided evidence to support the outbreak control team’s decision-making, leading to implementation of effective control measures in a timely manner.
- Subjects :
- 0301 basic medicine
Veterinary medicine
raw drinking milk
Epidemiology
030106 microbiology
Cattle Diseases
Biology
Escherichia coli O157
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Disease Outbreaks
Public access
03 medical and health sciences
RDM
fluids and secretions
Virology
Animals
Humans
Pathogen
Disease Notification
Escherichia coli Infections
Whole genome sequencing
whole genome sequencing
Shiga-Toxigenic Escherichia coli
Public Health, Environmental and Occupational Health
Outbreaks
Outbreak
Sequence Analysis, DNA
030104 developmental biology
Milk
England
Food Microbiology
Cattle
Shiga toxin-producing Escherichia coli O157
Genetic relatedness
Outbreak control
Sentinel Surveillance
gastrointestinal disease
Subjects
Details
- Language :
- English
- ISSN :
- 15607917 and 1025496X
- Volume :
- 24
- Issue :
- 16
- Database :
- OpenAIRE
- Journal :
- Eurosurveillance
- Accession number :
- edsair.doi.dedup.....f41c2378dea474628102b29b511b15c5