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Crystalline structures of l-cysteine and l-cystine
- Source :
- Amino Acids, Amino Acids, 2022, 53, pp.1123-1133. ⟨10.1007/s00726-022-03144-6⟩
- Publication Year :
- 2022
- Publisher :
- Springer Wien, 2022.
-
Abstract
- International audience; It is assumed that genetic diseases affecting the metabolism of cysteine and the kidney function lead to two different kinds of pathologies, namely cystinuria and cystinosis whereby generate L-cystine crystals. Recently, the presence of L-cysteine crystal has been underlined in the case of cystinosis. Interestingly, it can be strikingly seen that cystine ([-S-CH2-CH-(NH2)-COOH]2) consists of two cysteine (C3H7NO2S) molecules connected by a disulfide (S-S) bond. Therefore, the study of cystine and cysteine is important for providing a better understanding of cystinuria and cystinosis. In this paper, we elucidate the discrepancy between L-cystine and L-cysteine by investigating the theoretical and experimental infrared spectra (IR), X-ray diffraction (XRD) as well as Raman spectra aiming to obtain a better characterization of abnormal deposits related to these two genetic pathologies.
- Subjects :
- Cystinuria
[SDV]Life Sciences [q-bio]
Cystinosis
Organic Chemistry
Clinical Biochemistry
L-cystine
l-cysteine
l-cystine
[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
Biochemistry
[PHYS.PHYS.PHYS-CHEM-PH] Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph]
[SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences
[SDV] Life Sciences [q-bio]
Biominerals
Cystine
Humans
characterization
[PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph]
Cysteine
Disulfides
Crystalline structure
Computer simulations
Subjects
Details
- Language :
- English
- ISSN :
- 09394451 and 14382199
- Database :
- OpenAIRE
- Journal :
- Amino Acids, Amino Acids, 2022, 53, pp.1123-1133. ⟨10.1007/s00726-022-03144-6⟩
- Accession number :
- edsair.doi.dedup.....f41aa8ae014b0f45e62febefbe5f996f