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Relationship between paternal somatic health and assisted reproductive technology outcomes
Relationship between paternal somatic health and assisted reproductive technology outcomes
- Source :
- Fertility and sterility. 106(3)
- Publication Year :
- 2016
-
Abstract
- Objective To study the association between paternal medical comorbidities and the outcomes of assisted reproductive technology (ART). Design Retrospective cohort study. Setting Academic reproductive medicine center. Patient(s) We analyzed fresh ART cycles uszing freshly ejaculated sperm from the male partner of couples undergoing ART cycles from 2004 until 2014. We recorded patient and partner demographic characteristics. The cohort was linked to hospital billing data to obtain information on selected male partners' comorbidities identified using ICD-9-CM codes. Intervention(s) None. Main Outcome Measure(s) Fertilization, clinical pregnancy, miscarriage, implantation, and live-birth rates as well as birth weights and gestational ages. Result(s) In all, we identified 2,690 men who underwent 5,037 fresh ART cycles. Twenty-seven percent of men had at least one medical diagnosis. Men with nervous system diseases had on average lower pregnancy rates (23% vs. 30%) and live-birth rates (15% vs. 23%) than men without nervous system diseases. Lower fertilization rates were also observed among men with respiratory diseases (61% vs. 64%) and musculoskeletal diseases (61% vs. 64%) relative to those without these diseases. In addition, men with diseases of the endocrine system had smaller children (2,970 vs. 3,210 g) than men without such diseases. Finally, men with mental disorders had children born at an earlier gestational age (36.5 vs. 38.0 weeks). Conclusion(s) The current report identified a possible relationship between a man's health history and IVF outcomes. As these are potentially modifiable factors, further research should determine whether treatment for men's health conditions may improve or impair IVF outcomes.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Pregnancy Rate
medicine.medical_treatment
Health Status
Reproductive medicine
Comorbidity
Fertilization in Vitro
Miscarriage
03 medical and health sciences
Fathers
Young Adult
0302 clinical medicine
Pregnancy
Risk Factors
medicine
Humans
Embryo Implantation
Retrospective Studies
Gynecology
Academic Medical Centers
030219 obstetrics & reproductive medicine
Assisted reproductive technology
Obstetrics
business.industry
Obstetrics and Gynecology
Gestational age
Retrospective cohort study
Middle Aged
medicine.disease
Abortion, Spontaneous
030104 developmental biology
Fertility
Treatment Outcome
Reproductive Medicine
Infertility
Cohort
Female
Live birth
business
Live Birth
Subjects
Details
- ISSN :
- 15565653
- Volume :
- 106
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Fertility and sterility
- Accession number :
- edsair.doi.dedup.....f41a9b7fd7a40a3ced71625690b65825