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Synthesis of Amphiphilic Polythiophene for Cell Imaging and Monitoring the Cellular Distribution of a Cisplatin Anticancer Drug
- Source :
- Small. 7:1464-1470
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- A new amphiphilic conjugated polythiophene derivative (PT-Boc) is synthesized via Suzuki coupling reaction. The amphiphilic characteristic makes it form nanoaggregates in water, in which hydrophobic moieties come together to form the inner core. The polymer shows good photostability and no toxicity to human lung epithelial (A549) cells even at a high concentration (100 μg mL(-1) ). It therefore meets the crucial requirement for cellular imaging and other biological applications. The anticancer drug cisplatin is used as a model, and is linked to polythiophene to obtain a conjugate 'PT-Pt' by coordinated interactions between cisplatin and the amine groups of the polythiophene side chain. The PT-Pt can be used for monitoring the cellular distribution of cisplatin by fluorescence microscopy. The amphiphilic polythiophene provides a platform for fluorescent imaging of drugs and biological molecules in living cells.
- Subjects :
- Materials science
Cell Survival
Polymers
Stereochemistry
Antineoplastic Agents
Thiophenes
Conjugated system
Absorption
Biomaterials
Surface-Active Agents
chemistry.chemical_compound
Imaging, Three-Dimensional
Suzuki reaction
Cell Line, Tumor
Amphiphile
medicine
Side chain
Humans
General Materials Science
Cisplatin
chemistry.chemical_classification
Cell Death
Spectrum Analysis
Biomolecule
General Chemistry
Combinatorial chemistry
chemistry
Microscopy, Electron, Scanning
Polythiophene
Biotechnology
medicine.drug
Conjugate
Subjects
Details
- ISSN :
- 16136810
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Small
- Accession number :
- edsair.doi.dedup.....f414ee78b6cdc652ef2a85fd1727d28d