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Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials
- Source :
- Bioorganic & Medicinal Chemistry Letters. 13:4197-4200
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- Novel benzazepine oxazolidinone antibacterials were synthesized and evaluated against clinically relevant susceptible and resistant organisms. The effect of ring nitrogen position and N-substitution on antibacterial activity is examined.
- Subjects :
- medicine.drug_class
Stereochemistry
Clinical Biochemistry
Antibiotics
Pharmaceutical Science
Microbial Sensitivity Tests
Ring (chemistry)
Gram-Positive Bacteria
Biochemistry
Chemical synthesis
Benzazepine
Mice
Structure-Activity Relationship
chemistry.chemical_compound
Acetamides
Gram-Negative Bacteria
Drug Discovery
medicine
Animals
Molecular Biology
Oxazolidinones
Antibacterial agent
Biological evaluation
Bicyclic molecule
Chemistry
Organic Chemistry
Linezolid
General Medicine
Benzazepines
Combinatorial chemistry
Anti-Bacterial Agents
Molecular Medicine
Antibacterial activity
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....f412553a393313c530f61f78d80adeb3