The ATPase Inhibitory Factor 1 (IF1) regulates the expression of the mitochondrial Ca2+ uniporter (MCU) via the AMPK/CREB pathway

Authors :: Danilo Faccenda
Alessandra Baracca
Michelangelo Campanella
Claire Thornton
Giancarlo Solaini
Giulia Gorini
Adam Jones
Danilo Faccenda, Giulia Gorini, Adam Jonesa, Claire Thorntona, Alessandra Baracca, Giancarlo Solaini, Michelangelo Campanella
Publication Year :: 2021
Abstract: •IF1 regulates MCU-dependent mitochondrial Ca2+ uptake.\ud \ud •IF1 loss induces MCU upregulation through activation of the AMPK/CREB pathway.\ud \ud •OMA1 depletion restores physiological MCU levels and mitochondrial Ca2+ entry.

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