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Inflammasomes of the intestinal epithelium
- Source :
- Trends in Immunology
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- While the functional importance of inflammasomes in blood-derived cell types is well established, it remains poorly understood how inflammasomes in nonhematopoietic cells contribute to mucosal immunity. Recent studies have revealed functional roles of inflammasomes - particularly NAIP/NLRC4, NLRP6, and noncanonical caspase-4 (caspase-11) - within epithelial cells of the gut in mucosal immune defense, inflammation, and tumorigenesis. Here, we review and discuss these findings in the broader context of tissue compartment-specific mucosal immunity. We propose several models whereby activities of the intestinal epithelial inflammasomes converge on mechanisms to remove compromised epithelial cells, maintain host-microbiota mutualism, and communicate with immune cells of the underlying lamina propria.
Details
- ISSN :
- 14714906
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Trends in Immunology
- Accession number :
- edsair.doi.dedup.....f40f7ee12967e896aed64f59e657627b