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The Combined Effect of Weaning Stress and Immune Activation during Pig Gestation on Serum Cytokine and Analyte Concentrations
- Source :
- Animals, Vol 11, Iss 2274, p 2274 (2021), Animals, Volume 11, Issue 8, Animals : an Open Access Journal from MDPI
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Simple Summary The present study of blood chemical, cytokine and hormone indicators in male and female pigs offered insights into the combined effects of maternal immune activation and weaning stress. Our results indicate that maternal immune activation may grant higher tolerance to anion gap and bilirubin disruptions triggered by weaning stress. Therefore, management practices aimed at minimizing the effects of weaning should consider the interacting effect of immune activation during development. Abstract Weaning stress can elicit changes in the metabolic, hormone and immune systems of pigs and interact with prolonged disruptions stemming from maternal immune activation (MIA) during gestation. The present study advances the characterization of the combined effects of weaning stress and MIA on blood chemistry, immune and hormone indicators that inform on the health of pigs. Three-week-old female and male offspring of control gilts or gilts infected with the porcine reproductive and respiratory syndrome virus were allocated to weaned or nursed groups. The anion gap and bilirubin profiles suggest that MIA enhances tolerance to the effects of weaning stress. Interleukin 1 beta and interleukin 2 were highest among weaned MIA females, and cortisol was higher among weaned relative to nursed pigs across sexes. Canonical discriminant analysis demonstrated that weaned and nursed pigs have distinct chemistry profiles, whereas MIA and control pigs have distinct cytokine profiles. The results from this study can guide management practices that recognize the effects of the interaction between MIA and weaning stress on the performance and health of pigs.
- Subjects :
- 0301 basic medicine
Interleukin 2
medicine.medical_specialty
endocrine system diseases
Offspring
Veterinary medicine
interleukin 2
Article
03 medical and health sciences
anion gap
0302 clinical medicine
Immune system
Internal medicine
SF600-1100
medicine
Weaning
interleukin 1 beta
calcium
General Veterinary
biology
Porcine reproductive and respiratory syndrome virus
biology.organism_classification
030104 developmental biology
Endocrinology
Blood chemistry
QL1-991
Gestation
Animal Science and Zoology
bilirubin
Zoology
030217 neurology & neurosurgery
medicine.drug
Hormone
Subjects
Details
- Language :
- English
- ISSN :
- 20762615
- Volume :
- 11
- Issue :
- 2274
- Database :
- OpenAIRE
- Journal :
- Animals
- Accession number :
- edsair.doi.dedup.....f40c328772e0f6ad833ce68b050dc538