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Prospective Cohort Study of Infective Endocarditis in People Who Inject Drugs

Authors :
David R. Murdoch
Nuria Fernández-Hidalgo
Eugene Athan
Juan M. Pericàs
José M. Miró
Tomáš Freiberger
Pierre Tattevin
Emanuele Durante-Mangoni
Francisco Nacinovich
Marta Hernández-Meneses
Vivian H. Chu
Zeina A. Kanafani
Jacob Strahilevitz
Jaume Llopis
Cristiane da Cruz Lamas
Margaret M. Hannan
University of Barcelona
Deakin University [Burwood]
University of Otago [Dunedin, Nouvelle-Zélande]
American University of Beirut [Beyrouth] (AUB)
Masaryk University [Brno] (MUNI)
Hadassah Hebrew University Medical Center [Jerusalem]
Universitat Autònoma de Barcelona (UAB)
CHU Pontchaillou [Rennes]
ARN régulateurs bactériens et médecine (BRM)
Université de Rennes 1 (UR1)
Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Duke University [Durham]
This study was supported by the Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (# E26/202.782/2015 to Dr. Lamas), Red Española de Investigación en Patología Infecciosa (V-2003-REDC14A-O), and Fondo de Investigaciones Sanitarias de la Seguridad Social (FIS 00-0475) (Dr. Miro). Dr. Miro has received a personal 80:20 research grant from the Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, for 2017 to 2021. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Pericas, J. M.
Llopis, J.
Athan, E.
Hernandez-Meneses, M.
Hannan, M. M.
Murdoch, D. R.
Kanafani, Z.
Freiberger, T.
Strahilevitz, J.
Fernandez-Hidalgo, N.
Lamas, C.
Durante-Mangoni, E.
Tattevin, P.
Nacinovich, F.
Chu, V. H.
Miro, J. M.
Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Source :
Journal of the American College of Cardiology, Journal of the American College of Cardiology, Elsevier, 2021, 77 (5), pp.544-555. ⟨10.1016/j.jacc.2020.11.062⟩, Journal of the American College of Cardiology, 2021, 77 (5), pp.544-555. ⟨10.1016/j.jacc.2020.11.062⟩
Publication Year :
2021
Publisher :
HAL CCSD, 2021.

Abstract

International audience; Background - Infective endocarditis (IE) in people who inject drugs (PWID) is an emergent public health problem. Objectives - The purpose of this study was to investigate IE in PWID and compare it with IE in non-PWID patients. Methods - Two prospective cohort studies (ICE-PCS and ICE-Plus databases, encompassing 8,112 IE episodes from 2000 to 2006 and 2008 to 2012, with 64 and 34 sites and 28 and 18 countries, respectively). Outcomes were compared between PWID and non-PWID patients with IE. Logistic regression analyses were performed to investigate risk factors for 6-month mortality and relapses amongst PWID. Results - A total of 7,616 patients (591 PWID and 7,025 non-PWID) were included. PWID patients were significantly younger (median 37.0 years [interquartile range: 29.5 to 44.2 years] vs. 63.3 years [interquartile range: 49.3 to 74.0 years]; p

Details

Language :
English
ISSN :
07351097 and 15583597
Database :
OpenAIRE
Journal :
Journal of the American College of Cardiology, Journal of the American College of Cardiology, Elsevier, 2021, 77 (5), pp.544-555. ⟨10.1016/j.jacc.2020.11.062⟩, Journal of the American College of Cardiology, 2021, 77 (5), pp.544-555. ⟨10.1016/j.jacc.2020.11.062⟩
Accession number :
edsair.doi.dedup.....f404d5c9d3ac4a9ac1e727075fe523d4