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MYC Up-regulation Is a Useful Biomarker for Preoperative Neoadjuvant Chemotherapy Combined With Anti-EGFR in Liver Metastasis from Colorectal Cancer
- Source :
- In Vivo
- Publication Year :
- 2021
- Publisher :
- Anticancer Research USA Inc., 2021.
-
Abstract
- Background/aim At present, there are no biomarkers to predict the effects of molecular targeted drugs in patients with CRC with liver metastasis. Thus, we performed this study to explore potential biomarkers for these patients. Materials and methods We obtained cancer tissue specimens from liver metastasis-bearing CRC patients who received the following preoperative neoadjuvant chemotherapies with molecular targeted drugs: i) no therapy (n=3), ii) 5-FU+oxaliplatin+anti-EGFR (n=3), iii) and 5-FU+oxaliplatin+anti-VEGF (n=3). Results We investigated the RNA expression of 84 genes related to cancer drug resistance using an RT-PCR array. The MYC gene was the only gene that was significantly up-regulated in CRC tissue specimens from anti-EGFR group in comparison to the anti-VEGF group. Conclusion MYC up-regulation in the primary CRC tissues may be a potentially useful biomarker for selecting anti-EGFR combination therapy in neoadjuvant chemotherapy for CRC with liver metastasis.
- Subjects :
- Cancer Research
Combination therapy
Colorectal cancer
medicine.medical_treatment
General Biochemistry, Genetics and Molecular Biology
Metastasis
Downregulation and upregulation
medicine
Humans
Pharmacology
Chemotherapy
business.industry
Liver Neoplasms
Cancer
medicine.disease
Neoadjuvant Therapy
digestive system diseases
Up-Regulation
Oxaliplatin
Cancer research
Biomarker (medicine)
Colorectal Neoplasms
business
Biomarkers
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 17917549 and 0258851X
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- In Vivo
- Accession number :
- edsair.doi.dedup.....f4005b34d62670685ac42de65811886e