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An overview of biotransformation and toxicity of diterpenes
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, Molecules, Vol 23, Iss 6, p 1387 (2018)
- Publication Year :
- 2018
-
Abstract
- Diterpenes have been identified as active compounds in several medicinal plants showing remarkable biological activities, and some isolated diterpenes are produced at commercial scale to be used as medicines, food additives, in the synthesis of fragrances, or in agriculture. There is great interest in developing methods to obtain derivatives of these compounds, and biotransformation processes are interesting tools for the structural modification of natural products with complex chemical structures. Biotransformation processes also have a crucial role in drug development and/or optimization. The understanding of the metabolic pathways for both phase I and II biotransformation of new drug candidates is mandatory for toxicity and efficacy evaluation and part of preclinical studies. This review presents an overview of biotransformation processes of diterpenes carried out by microorganisms, plant cell cultures, animal and human liver microsomes, and rats, chickens, and swine in vivo and highlights the main enzymatic reactions involved in these processes and the role of diterpenes that may be effectively exploited by other fields.
- Subjects :
- Drug
food.ingredient
media_common.quotation_subject
Pharmaceutical Science
Review
01 natural sciences
Analytical Chemistry
lcsh:QD241-441
food
lcsh:Organic chemistry
Biotransformation
Drug Discovery
Animals
Humans
Physical and Theoretical Chemistry
Medicinal plants
media_common
Molecular Structure
Human liver
010405 organic chemistry
Chemistry
Food additive
Organic Chemistry
toxicity
diterpenes
0104 chemical sciences
010404 medicinal & biomolecular chemistry
Metabolic pathway
Biochemistry
Drug development
Chemistry (miscellaneous)
Toxicity
FARMACOCINÉTICA
Molecular Medicine
biotransformation
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP, Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, Molecules, Vol 23, Iss 6, p 1387 (2018)
- Accession number :
- edsair.doi.dedup.....f3ffb9e26e78b27d1b40f83506ec349a