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Comparative analysis of Lacistema pubescens and dexamethasone on topical treatment of skin inflammation in a chronic disease model and side effects
- Source :
- Journal of Pharmacy and Pharmacology. 70:576-582
- Publication Year :
- 2018
- Publisher :
- Oxford University Press (OUP), 2018.
-
Abstract
- Objectives This study aimed to evaluate the chronic topical anti-inflammatory activity of the pharmaceutical formulation ProHLP containing the hexane fraction of Lacistema pubescens (HLP). It was also investigated the possible cutaneous and systemic adverse effects of HLP and ProHLP in mice when compared to dexamethasone. Methods The chronic topical anti-inflammatory activity was determined by croton oil multiple application-induced mouse ear oedema model. Histopathological analyses of ear tissue samples sensitized with croton oil were performed. Cutaneous atrophy induced by HLP and topical glucocorticoid treatments and excision skin wounds model to evidenced possible adverse reactions were also determined. Key findings ProHLP significantly reduced the mice ear oedema and considerably accelerated the wound-healing process. Also, HLP did not lead cutaneous atrophy and preserved the clinical aspect of the thymus, adrenal and spleen, unlike dexamethasone. Conclusions The results suggested that ProHLP is an efficient and safer pharmaceutical formulation to treat chronic inflammatory diseases.
- Subjects :
- Male
Administration, Topical
Anti-Inflammatory Agents
Pharmaceutical Science
Dermatitis
Inflammation
Spleen
Thymus Gland
Pharmacology
Dexamethasone
Mice
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Atrophy
Adrenal Glands
medicine
Animals
Edema
Croton oil
Adverse effect
Plant Extracts
business.industry
medicine.disease
Disease Models, Animal
Treatment Outcome
medicine.anatomical_structure
Chronic disease
030220 oncology & carcinogenesis
Chronic Disease
medicine.symptom
Wound healing
business
medicine.drug
Subjects
Details
- ISSN :
- 20427158 and 00223573
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacy and Pharmacology
- Accession number :
- edsair.doi.dedup.....f3fd8057dc1baa38317e18c2f3fcc63e