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NCX 1741, a Novel Nitric Oxide-Donating Phosphodiesterase-5 Inhibitor, Exerts Rapid and Long-Lasting Intraocular Pressure-Lowering in Cynomolgus Monkeys
- Source :
- Journal of Ocular Pharmacology and Therapeutics. 37:215-222
- Publication Year :
- 2021
- Publisher :
- Mary Ann Liebert Inc, 2021.
-
Abstract
- Purpose: We studied the IOP-lowering effects of NCX 1741, a novel nitric oxide (NO)-donating derivative of the phosphodiesterase type-5 inhibitor, avanafil, in Cynomolgus monkey with laser-induced ...
- Subjects :
- Long lasting
Intraocular pressure
genetic structures
medicine.drug_mechanism_of_action
Avanafil
Pharmacology
Dinoprost
Nitric Oxide
Nitric oxide
Aqueous Humor
Tonometry, Ocular
chemistry.chemical_compound
Travoprost
Tandem Mass Spectrometry
medicine
Animals
Nitric Oxide Donors
Pharmacology (medical)
Antihypertensive Agents
Intraocular Pressure
Phosphodiesterase
Phosphodiesterase 5 Inhibitors
Macaca fascicularis
Ophthalmology
Pyrimidines
chemistry
Models, Animal
Anti-Infective Agents, Local
Female
Ocular Hypertension
Rabbits
Benzalkonium Compounds
Phosphodiesterase 5 inhibitor
Derivative (chemistry)
Chromatography, Liquid
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 15577732 and 10807683
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Journal of Ocular Pharmacology and Therapeutics
- Accession number :
- edsair.doi.dedup.....f3e4c01c0a204f4cd578f3d9d21869c3
- Full Text :
- https://doi.org/10.1089/jop.2020.0126