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Neuritic and Diffuse Plaque Associations with Memory in Non-Cognitively Impaired Elderly
- Publication Year :
- 2016
-
Abstract
- The presence of Alzheimer's disease (AD)-related neuropathology among cognitively normal individuals has been well documented. It has been proposed that these individuals may represent a pre-clinical AD population. Previous studies have demonstrated a negative association between the presence of both amyloid-β (Aβ) plaques and neurofibrillary tangles with ante-mortem cognitive performance, a relationship which is likely influenced by a number of factors including age and APOE ɛ4 carrier status. The present study determined whether the presence of neuritic plaques (NPs) and diffuse plaques (DPs) are associated with performance in a number of cognitive domains after accounting for APOE ɛ4 carrier status and neurofibrillary tangle presence in a cohort of 123 older participants from the Rush Religious Order Study who died with a premortem clinical diagnosis of no cognitive impairment (NCI). After adjusting for age at death, education, gender, Braak stage, and APOE ɛ4 carrier status, the presence of NPs was associated with lower performance in the cognitive domains of Global Cognition (p = 0.002), Episodic Memory (p = 0.03), Semantic Memory (p = 0.009), and Visuospatial performance (p = 0.006), while DPs showed no association with any cognitive domain examined. These results suggest that decreases in cognition in elderly NCI individuals are associated with an increase in NPs and not DPs when age at death, education, gender, APOE ɛ4 status, and Braak stage are taken into consideration.
- Subjects :
- 0301 basic medicine
Oncology
Male
medicine.medical_specialty
Aging
Memory, Episodic
Population
Apolipoprotein E4
Plaque, Amyloid
Neuropathology
Neuropsychological Tests
Article
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Memory
Internal medicine
medicine
Semantic memory
Humans
Effects of sleep deprivation on cognitive performance
Senile plaques
education
Episodic memory
Aged
Aged, 80 and over
education.field_of_study
business.industry
General Neuroscience
Brain
Cognition
Neurofibrillary tangle
Neurofibrillary Tangles
General Medicine
medicine.disease
Psychiatry and Mental health
Clinical Psychology
030104 developmental biology
Female
Autopsy
Geriatrics and Gerontology
business
Cognition Disorders
Mental Status Schedule
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....f3e498d5acf1fb3f0bb4e028618822e7