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Phonatory function in patients with well-differentiated thyroid carcinoma following meticulous resection of tumors adhering to the recurrent laryngeal nerve
- Source :
- International journal of clinical oncology. 24(12)
- Publication Year :
- 2019
-
Abstract
- Well-differentiated thyroid carcinomas (WDTCs) sometimes adhere firmly to the recurrent laryngeal nerve (RLN), while allowing normal mobility of the vocal fold (VF). Meticulous dissection of the adhered tumor from the RLN is known to be effective, preserving VF mobility and oncological safety. However, phonatory function following this preservation procedure has yet to be evaluated sufficiently. The objective of this study was to examine phonatory function following the preservation procedure. Ten patients with WDTCs, demonstrating normal preoperative VF mobility with tumors adhering to the RLN, underwent the preservation procedure between 2000 and 2013 (preservation group). During the same period, nine patients with WDTCs demonstrating normal VF mobility underwent resection and reconstruction of the tumor-invaded RLNs (reconstruction group). Phonatory function, including maximum phonation time (MPT), mean flow rate (MFR), jitter, shimmer, harmonics-to-noise ratio, and GRBAS scale score, was evaluated and compared statistically between the two groups. The mean values of MPT and MFR in the preservation group were at normal levels. Both G and B scores of GRBAS scale were at near-normal levels. Additionally, the mean B score of the GRBAS scale was significantly better in the preservation group than in the reconstruction group. When normal VF mobility is observed preoperatively, meticulous resection for preserving RLN would contribute to maintain not only normal level of MPT and MFR, but also to provide better B score of GRBAS scale than RLN resection followed by immediate reconstruction.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
GRBAS scale
Vocal Cords
Resection
03 medical and health sciences
0302 clinical medicine
Phonation
Recurrent laryngeal nerve
medicine
Humans
In patient
Thyroid Neoplasms
Aged
business.industry
Recurrent Laryngeal Nerve
Maximum phonation time
Normal level
Hematology
General Medicine
Middle Aged
Carcinoma, Papillary
Surgery
Dissection
030104 developmental biology
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Thyroidectomy
Female
business
Well Differentiated Thyroid Carcinoma
Organ Sparing Treatments
Vocal Cord Paralysis
Subjects
Details
- ISSN :
- 14377772
- Volume :
- 24
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- International journal of clinical oncology
- Accession number :
- edsair.doi.dedup.....f3deb2d4ffa59ef8edc33076f69676b4