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Polymorphisms of plasminogen activator inhibitor-1, angiotensin converting enzyme and coagulation factor XIII genes in patients with recurrent spontaneous abortion
- Source :
- The Journal of Maternal-Fetal & Neonatal Medicine. 24:545-548
- Publication Year :
- 2010
- Publisher :
- Informa UK Limited, 2010.
-
Abstract
- We investigated polymorphisms of plasminogen activator inhibitor-1 (PAI-1), angiotensin converting enzyme (ACE ) and coagulation factor XIII (FXIII) genes and their association with recurrent spontaneous abortion (RSA) in Iranian patients and normal healthy controls. Ten (18.5%) patients were homozygote (4G/4G) for PAI-1 polymorphism, in contrast with two (2%) controls (p = 0.001). Patients with homozygote 4G mutation were significantly more prone to RSA in contrast to others (odds ratio: 11.0, 95% CI: 2.3-52.4). Nineteen (30.2%) patients and 25 (26.6%) controls were homozygote (DD) for ACE polymorphism. We observed only two patients and one control with homozygosity (34leu) for FXIII polymorphism. 4G/4G polymorphism for PAI-1 gene could be a thrombophilic mutation leading to abortion in Iranian population.
- Subjects :
- Adult
Abortion, Habitual
medicine.medical_specialty
Genotype
Iran
Peptidyl-Dipeptidase A
Thrombophilia
chemistry.chemical_compound
Gene Frequency
Pregnancy
Polymorphism (computer science)
Internal medicine
Plasminogen Activator Inhibitor 1
medicine
Humans
Polymorphism, Genetic
Factor XIII
biology
business.industry
Case-control study
Obstetrics and Gynecology
Angiotensin-converting enzyme
medicine.disease
Abortion, Spontaneous
Endocrinology
chemistry
Case-Control Studies
Plasminogen activator inhibitor-1
Pediatrics, Perinatology and Child Health
biology.protein
Female
business
Plasminogen activator
Genome-Wide Association Study
medicine.drug
Subjects
Details
- ISSN :
- 14764954 and 14767058
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- The Journal of Maternal-Fetal & Neonatal Medicine
- Accession number :
- edsair.doi.dedup.....f3d7a6f90891995786fb02699555deef
- Full Text :
- https://doi.org/10.3109/14767058.2010.511331