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NAD+ in Brain Aging and Neurodegenerative Disorders
- Source :
- Cell Metabolism. 30:630-655
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findings that reveal key roles for NAD+ and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurring in Alzheimer’s, Parkinson’s, and Huntington diseases, and amyotrophic lateral sclerosis. Advances in understanding the molecular and cellular mechanisms of NAD+-based neuronal resilience will lead to novel approaches for facilitating healthy brain aging and for the treatment of a range of neurological disorders.
- Subjects :
- 0301 basic medicine
Parkinson's disease
Physiology
Neurodegeneration
Cell Biology
Mitochondrion
Biology
medicine.disease
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Synaptic plasticity
Neuroplasticity
Mitophagy
medicine
NAD+ kinase
Amyotrophic lateral sclerosis
Molecular Biology
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15504131
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Cell Metabolism
- Accession number :
- edsair.doi.dedup.....f3cb6bd316e089d7409ac658455ccf82