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Arterial Carboxyhemoglobin Measurement Is Useful for Evaluating Pulmonary Inflammation in Subjects with Interstitial Lung Disease
- Source :
- Internal Medicine
- Publication Year :
- 2017
-
Abstract
- Objective The arterial concentration of carboxyhemoglobin (CO-Hb) in subjects with inflammatory pulmonary disease is higher than that in healthy individuals. We retrospectively analyzed the relationship between the CO-Hb concentration and established markers of disease severity in subjects with interstitial lung disease (ILD). Methods The CO-Hb concentration was measured in subjects with newly diagnosed or untreated ILD and the relationships between the CO-Hb concentration and the serum biomarker levels, lung function, high-resolution CT (HRCT) findings, and the uptake in gallium-67 (67Ga) scintigraphy were evaluated. Results Eighty-one non-smoking subjects were studied (mean age, 67 years). Among these subjects, (A) 17 had stable idiopathic pulmonary fibrosis (IPF), (B) 9 had an acute exacerbation of IPF, (C) 44 had stable non-IPF, and (D) 11 had an exacerbation of non-IPF. The CO-Hb concentrations of these subjects were (A) 1.5±0.5%, (B) 2.1±0.5%, (C) 1.2±0.4%, and (D) 1.7±0.5%. The CO-Hb concentration was positively correlated with the serum levels of surfactant protein (SP)-A (r=0.38), SP-D (r=0.39), and the inflammation index (calculated from HRCT; r=0.57) and was negatively correlated with the partial pressure of oxygen in the arterial blood (r=-0.56) and the predicted diffusion capacity of carbon monoxide (r=-0.61). The CO-Hb concentrations in subjects with a negative heart sign on 67Ga scintigraphy were higher than those in subjects without a negative heart sign (1.4±0.5% vs. 1.1±0.3%, p=0.018). Conclusion The CO-Hb levels of subjects with ILD were increased, particularly during an exacerbation, and were correlated with the parameters that reflect pulmonary inflammation.
- Subjects :
- Adult
Male
medicine.medical_specialty
Exacerbation
Inflammation
Carboxyhemoglobin Measurement
Scintigraphy
pulmonary inflammation
03 medical and health sciences
chemistry.chemical_compound
Idiopathic pulmonary fibrosis
0302 clinical medicine
exacerbation
Internal medicine
Internal Medicine
Medicine
Humans
Aged
Retrospective Studies
Aged, 80 and over
medicine.diagnostic_test
Pulmonary Surfactant-Associated Protein A
business.industry
Interstitial lung disease
negative heart sign
General Medicine
Pneumonia
respiratory system
Middle Aged
medicine.disease
idiopathic pulmonary fibrosis
surfactant proteins
respiratory tract diseases
Oxygen
030228 respiratory system
chemistry
Carboxyhemoglobin
030220 oncology & carcinogenesis
Cardiology
Arterial blood
Female
Original Article
medicine.symptom
business
Lung Diseases, Interstitial
Biomarkers
Subjects
Details
- ISSN :
- 13497235
- Volume :
- 56
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Internal medicine (Tokyo, Japan)
- Accession number :
- edsair.doi.dedup.....f3b84056fe1347ce1ed968105f41d6be