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Sex, racial differences and healthy aging in normative reference ranges on diastolic function in Ethnic Asians: 2016 ASE guideline revisited
- Source :
- Journal of the Formosan Medical Association, Vol 120, Iss 12, Pp 2160-2175 (2021)
- Publication Year :
- 2020
-
Abstract
- Background: Diastolic dysfunction (DD) has shown to be a hallmark pathological intermediate in the development of heart failure with preserved ejection fraction (HFpEF). We aim to establish age- and sex-stratified normal reference values of diastolic indices and to explore racial-differences. Methods: We explored age- and sex-related structural/functional alterations from 6023 healthy ethnic Asians (47.1 ± 10.9 years, 61.3% men) according to 2016 American Society of Echocardiography (ASE) diastolic dysfunction (DD) criteria. Racial comparisons were made using data from London Life Sciences Prospective Population (LOLIPOP) study. Results: Age- and sex-based normative ranges (including mean, median, 10% and 90% lower and upper reference values) were extracted from our large healthy population. In fully adjusted models, advanced age was independently associated with cardiac structural remodeling and worsened diastolic parameters including larger indexed LA volume (LAVi), lower e’, higher E/e’, and higher TR velocity; all p
- Subjects :
- Male
medicine.medical_specialty
Medicine (General)
Diastolic dysfunction (DD)
Population
Diastole
Ethnic group
Ethnic asians
Healthy Aging
American Society of echocardiography (ASE)
R5-920
Asian People
Reference Values
Internal medicine
medicine
Humans
Prospective Studies
education
Pathological
Heart Failure
education.field_of_study
business.industry
N-terminal pro-brain natriuretic peptide (NT-proBNP)
Stroke Volume
General Medicine
Guideline
Race Factors
Heart failure (HF)
Echocardiography
Cohort
Cardiology
Normative
Female
Heart failure with preserved ejection fraction
business
Subjects
Details
- ISSN :
- 09296646
- Volume :
- 120
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of the Formosan Medical Association = Taiwan yi zhi
- Accession number :
- edsair.doi.dedup.....f3ab31ab0d11aa24f4bb66f83dce50c7