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Differential Temporal Perception Abilities in Parkinson’s Disease Patients Based on Timing Magnitude
- Source :
- Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019), Scientific Reports
- Publication Year :
- 2019
- Publisher :
- Nature Publishing Group, 2019.
-
Abstract
- Non-motor symptoms in Parkinson’s Disease (PD) predate motor symptoms and substantially decrease quality of life; however, detection, monitoring, and treatments are unavailable for many of these symptoms. Temporal perception abnormalities in PD are generally attributed to altered Basal Ganglia (BG) function. Present studies are confounded by motor control facilitating movements that are integrated into protocols assessing temporal perception. There is uncertainty regarding the BG’s influence on timing processes of different time scales and how PD therapies affect this perception. In this study, PD patients using Levodopa (n = 25), Deep Brain Stimulation (DBS; n = 6), de novo patients (n = 6), and healthy controls (n = 17) completed a visual temporal perception task in seconds and sub-section timing scales using a computer-generated graphical tool. For all patient groups, there were no impairments seen at the smaller tested magnitudes (using sub-second timing). However, all PD groups displayed significant impairments at the larger tested magnitudes (using interval timing). Neither Levodopa nor DBS therapy led to significant improvements in timing abilities. Levodopa resulted in a strong trend towards impairing timing processes and caused a deterioration in perceptual coherency according to Weber’s Law. It is shown that timing abnormalities in PD occur in the seconds range but do not extend to the sub-second range. Furthermore, observed timing deficits were shown to not be solely caused by motor deficiency. This provides evidence to support internal clock models involving the BG (among other neural regions) in interval timing, and cerebellar control of sub-second timing. This study also revealed significant temporal perception deficits in recently diagnosed PD patients; thus, temporal perception abnormalities might act as an early disease marker, with the graphical tool showing potential for disease monitoring.
- Subjects :
- Male
medicine.medical_specialty
Levodopa
Visual perception
Deep brain stimulation
Parkinson's disease
Deep Brain Stimulation
medicine.medical_treatment
media_common.quotation_subject
Neurophysiology
lcsh:Medicine
Audiology
Article
Basal Ganglia
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
Perception
Basal ganglia
Humans
Medicine
0501 psychology and cognitive sciences
lcsh:Science
Aged
media_common
Multidisciplinary
business.industry
05 social sciences
lcsh:R
Motor control
Parkinson Disease
Middle Aged
Time perception
medicine.disease
Time Perception
Visual Perception
Female
lcsh:Q
business
Neurological disorders
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....f3a6fe219cad3bac7d3591cbec18fcb8