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Mechanisms of local invasion in enteroendocrine tumors: Identification of novel candidate cytoskeleton-associated proteins in an experimental mouse model by a proteomic approach and validation in human tumors
- Source :
- Molecular and Cellular Endocrinology, Molecular and Cellular Endocrinology, Elsevier, 2015, 399, pp.154-163. ⟨10.1016/j.mce.2014.09.006⟩, Molecular and Cellular Endocrinology, 2015, 399, pp.154-163. ⟨10.1016/j.mce.2014.09.006⟩, Molecular and Cellular Endocrinology, Vol. 399 (2015) pp. 154-163
- Publication Year :
- 2015
- Publisher :
- HAL CCSD, 2015.
-
Abstract
- Small-intestinal neuroendocrine tumors (SI-NETs) are defined as locally invasive only after extension to the muscularis propria. To gain further insight into the molecular mechanisms, we applied a proteomic approach to an orthotopic xenograft model to identify candidate proteins evaluable in human SI-NETs. After grafting STC-1 neuroendocrine tumor cells on the caecum of nude mice, comparative proteomic studies were performed between the pre-invasive and the invasive stages, respectively 2 and 8 weeks after grafting. We identified 24 proteins displaying at least a 1.5-fold differential expression between 2 and 8 week-stages. Most were cytoskeleton-associated proteins, among which five showed decreasing expression levels (CRMP2, TCP1e, TPM2, vimentin, desmin) and two increasing expression levels (14-3-3γ, CK8). Changes for CRMP2, TCP1e, TPM2 and 14-3-3γ were confirmed in experimental tumors and in a series of 28 human SI-NETs. In conclusion, our results underline the relevance of proteomics to identify novel biomarkers of tissue invasion.
- Subjects :
- Proteomics
Enteroendocrine Cells
[SDV]Life Sciences [q-bio]
Mice, Nude
Vimentin
Enteroendocrine cell
Mice, Transgenic
Biology
Neuroendocrine tumors
Bioinformatics
Biochemistry
Mice
Endocrinology
Cell Line, Tumor
Intestinal Neoplasms
medicine
Animals
Humans
ddc:576
Cytoskeleton
Molecular Biology
ComputingMilieux_MISCELLANEOUS
medicine.disease
Neoplasm Proteins
Gene Expression Regulation, Neoplastic
Cytoskeletal Proteins
Cancer research
biology.protein
Tissue invasion
Desmin
Collapsin response mediator protein family
Neoplasm Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 03037207
- Database :
- OpenAIRE
- Journal :
- Molecular and Cellular Endocrinology, Molecular and Cellular Endocrinology, Elsevier, 2015, 399, pp.154-163. ⟨10.1016/j.mce.2014.09.006⟩, Molecular and Cellular Endocrinology, 2015, 399, pp.154-163. ⟨10.1016/j.mce.2014.09.006⟩, Molecular and Cellular Endocrinology, Vol. 399 (2015) pp. 154-163
- Accession number :
- edsair.doi.dedup.....f39d47ac4df32a29d994b43fbe776d72