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Ultrasonic differentiation of normal versus malignant breast epithelial cells in monolayer cultures
- Publication Year :
- 2010
- Publisher :
- Acoustical Society of America, 2010.
-
Abstract
- Normal and malignant mammary epithelial cells were studied using laboratory measurements, wavelet analysis, and numerical simulations of monolayer cell cultures to determine whether microscopic breast cancer can be detected in vitro with high-frequency ultrasound. Pulse-echo waveforms were acquired by immersing a broadband, unfocused 50-MHz transducer in the growth media of cell culture well plates and collecting the first reflection from the well bottoms. The simulations included a multilayer pulse-reflection model and a model of two-dimensional arrays of spherical cells and nuclei. The results show that normal and malignant cells produce time-domain signals and spectral features that are significantly different.
- Subjects :
- Acoustics and Ultrasonics
Cell Culture Techniques
Wavelet Analysis
Breast Neoplasms
Breast cancer
Arts and Humanities (miscellaneous)
Cell Line, Tumor
Monolayer
medicine
Malignant cells
Humans
Ultrasonics
Cellular biophysics
Ultrasonography
Chemistry
business.industry
Ultrasound
Epithelial Cells
medicine.disease
In vitro
Jasa Express Letters
Cell culture
Ultrasonic sensor
Female
business
Biomedical engineering
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....f397722172971b0eb3c4d2061f7d2e1a