Back to Search Start Over

Study of 8 Types of Glutathione Peroxidase Mimics Based on β-Cyclodextrin

Authors :
Xiaonan Qu
Ying Xie
Shao-Wu Lv
Liwu Wang
Source :
Catalysts, Vol 7, Iss 10, p 289 (2017), Catalysts; Volume 7; Issue 10; Pages: 289
Publication Year :
2017
Publisher :
MDPI AG, 2017.

Abstract

Glutathione peroxidase is key for the removal of H2O2 and other hydroperoxides and therefore, it has an important role in the maintenance of the reactive oxygen species (ROS) metabolic balance in vivo. The native enzymes of the glutathione peroxidase family (GPx) have many defects, such as instability in vitro and poor availability. GPx mimetics has become a topic of considerable interest in artificial enzyme research. Many forms of GPx mimics have been synthesized, by including selenium and tellurium (double-bridged and single-bridged, 2-substituted and 6-substituted) in a mother molecule but differences the GPx mimics enzymatic activity have rarely been compared. We designed and synthesized eight cyclodextrin derivatives and used two types of enzyme assays to determine their activities. The results show that: (a) tellurium-containing GPx mimics have higher activity than that of selenium-containing GPx mimics; (b) dual-bridged mimics have higher activity than bis-bridged mimics; and (c) 2-position modified cyclodextrin has higher activity than 6-position modified cyclodextrin.

Details

Language :
English
ISSN :
20734344
Volume :
7
Issue :
10
Database :
OpenAIRE
Journal :
Catalysts
Accession number :
edsair.doi.dedup.....f396c903285d2c9bfc4e181365287bdc