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Study of 8 Types of Glutathione Peroxidase Mimics Based on β-Cyclodextrin
- Source :
- Catalysts, Vol 7, Iss 10, p 289 (2017), Catalysts; Volume 7; Issue 10; Pages: 289
- Publication Year :
- 2017
- Publisher :
- MDPI AG, 2017.
-
Abstract
- Glutathione peroxidase is key for the removal of H2O2 and other hydroperoxides and therefore, it has an important role in the maintenance of the reactive oxygen species (ROS) metabolic balance in vivo. The native enzymes of the glutathione peroxidase family (GPx) have many defects, such as instability in vitro and poor availability. GPx mimetics has become a topic of considerable interest in artificial enzyme research. Many forms of GPx mimics have been synthesized, by including selenium and tellurium (double-bridged and single-bridged, 2-substituted and 6-substituted) in a mother molecule but differences the GPx mimics enzymatic activity have rarely been compared. We designed and synthesized eight cyclodextrin derivatives and used two types of enzyme assays to determine their activities. The results show that: (a) tellurium-containing GPx mimics have higher activity than that of selenium-containing GPx mimics; (b) dual-bridged mimics have higher activity than bis-bridged mimics; and (c) 2-position modified cyclodextrin has higher activity than 6-position modified cyclodextrin.
- Subjects :
- GPX3
mimic enzyme
010402 general chemistry
lcsh:Chemical technology
01 natural sciences
Catalysis
GPX6
lcsh:Chemistry
lcsh:TP1-1185
Physical and Theoretical Chemistry
glutathione peroxidase
chemistry.chemical_classification
Reactive oxygen species
biology
Cyclodextrin
010405 organic chemistry
Artificial enzyme
cyclodextrin derivatives
Glutathione peroxidase
Enzyme assay
0104 chemical sciences
enzyme activity
kinetics
Enzyme
chemistry
Biochemistry
lcsh:QD1-999
biology.protein
Subjects
Details
- Language :
- English
- ISSN :
- 20734344
- Volume :
- 7
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Catalysts
- Accession number :
- edsair.doi.dedup.....f396c903285d2c9bfc4e181365287bdc