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Effectiveness of robust optimization in volumetric modulated arc therapy using 6 and 10 MV flattening filter-free beam therapy planning for lung stereotactic body radiation therapy with a breath-hold technique
- Source :
- Journal of Radiation Research
- Publication Year :
- 2019
-
Abstract
- We investigated the feasibility of a robust optimization with 6 MV X-ray (6X) and 10 MV X-ray (10X) flattening filter-free (FFF) beams in a volumetric modulated arc therapy (VMAT) plan for lung stereotactic body radiation therapy (SBRT) using a breath-holding technique. Ten lung cancer patients were selected. Four VMAT plans were generated for each patient; namely, an optimized plan based on the planning target volume (PTV) margin and a second plan based on a robust optimization of the internal target volume (ITV) with setup uncertainties, each for the 6X- and 10X-FFF beams. Both optimized plans were normalized by the percentage of the prescription dose covering 95% of the target volume (D95%) to the PTV (1050 cGy × 4 fractions). All optimized plans were evaluated using perturbed doses by specifying user-defined shifted values from the isocentre. The average perturbed D99% doses to the ITV, compared to the nominal plan, decreased by 369.1 (6X-FFF) and 301.0 cGy (10X-FFF) for the PTV-based optimized plan, and 346.0 (6X-FFF) and 271.6 cGy (10X-FFF) for the robust optimized plan, respectively. The standard deviation of the D99% dose to the ITV were 163.6 (6X-FFF) and 158.9 cGy (10X-FFF) for the PTV-based plan, and 138.9 (6X-FFF) and 128.5 cGy (10X-FFF) for the robust optimized plan, respectively. Robust optimized plans with 10X-FFF beams is a feasible method to achieve dose certainty for the ITV for lung SBRT using a breath-holding technique.
- Subjects :
- Male
Organs at Risk
Lung Neoplasms
Stereotactic body radiation therapy
Health, Toxicology and Mutagenesis
Planning target volume
robust optimization
perturbed dose
VMAT
Therapy planning
Radiation Dosage
Radiosurgery
Standard deviation
030218 nuclear medicine & medical imaging
Oncology/Medicine
Breath Holding
03 medical and health sciences
0302 clinical medicine
Regular Paper
Humans
Radiology, Nuclear Medicine and imaging
Lung
Mathematics
Aged
Aged, 80 and over
Radiation
Flattening filter free
business.industry
Radiotherapy Planning, Computer-Assisted
Robust optimization
Radiotherapy Dosage
dose uncertainty
Middle Aged
Volumetric modulated arc therapy
030220 oncology & carcinogenesis
AcademicSubjects/SCI00960
Female
Radiotherapy, Intensity-Modulated
AcademicSubjects/MED00870
Nuclear medicine
business
Beam (structure)
Subjects
Details
- ISSN :
- 13499157
- Volume :
- 61
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of radiation research
- Accession number :
- edsair.doi.dedup.....f38f2aec682bb43e3af4ad31ef1eb20a