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The Absence of Laminin α4 in Male Mice Results in Enhanced Energy Expenditure and Increased Beige Subcutaneous Adipose Tissue
- Source :
- Endocrinology
- Publication Year :
- 2017
- Publisher :
- Endocrine Society, 2017.
-
Abstract
- Laminin α4 (LAMA4) is located in the extracellular basement membrane that surrounds each individual adipocyte. Here we show that LAMA4 null (Lama4−/−) mice exhibit significantly higher energy expenditure (EE) relative to wild-type (WT) mice at room temperature and when exposed to a cold challenge, despite similar levels of food intake and locomotor activity. The Lama4−/− mice are resistant to age- and diet-induced obesity. Expression of uncoupling protein 1 is higher in subcutaneous white adipose tissue of Lama4−/− mice relative to WT animals on either a chow diet or a high-fat diet. In contrast, uncoupling protein 1 expression was not increased in brown adipose tissue. Lama4−/− mice exhibit significantly improved insulin sensitivity compared with WT mice, suggesting improved metabolic function. Overall, these data provide critical evidence for a role of the basement membrane in EE, weight gain, and systemic insulin sensitivity.<br />Despite similar food consumption and activity, mice lacking basement membrane protein laminin α4 were resistant to obesity and had increased beige subcutaneous adipose tissue and energy expenditure.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Subcutaneous Fat
White adipose tissue
Diet, High-Fat
Weight Gain
Basement Membrane
03 medical and health sciences
chemistry.chemical_compound
Endocrinology
Adipose Tissue, Brown
Laminin
Stress, Physiological
Internal medicine
Adipocyte
Energy Balance - Obesity - Metabolism
Brown adipose tissue
medicine
Extracellular
Animals
Obesity
Research Articles
Cells, Cultured
Uncoupling Protein 1
Adiposity
Basement membrane
Mice, Knockout
030102 biochemistry & molecular biology
biology
Gene Expression Regulation, Developmental
Adipose Tissue, Beige
Thermogenin
Cold Temperature
Adult Stem Cells
030104 developmental biology
medicine.anatomical_structure
chemistry
Organ Specificity
biology.protein
medicine.symptom
Insulin Resistance
Energy Intake
Energy Metabolism
Weight gain
Subjects
Details
- Language :
- English
- ISSN :
- 19457170 and 00137227
- Volume :
- 159
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Endocrinology
- Accession number :
- edsair.doi.dedup.....f38c2265ae665dafceca1244fbe6502c