Simple Total Syntheses of (+)-Castanospermine and (+)-6-Epicastanospermine Using Indium-Mediated Allylation

The indium-mediated allylation of u-aminoaldehyde 3 from D-glucono-δ-lactone provided the syn-aminoalcohol with excellent diastereoselectivity. syn-Aminoalcohol was easily applied to the total syntheses of the potent glycosidase inhibitors; (+)-castano-spermine and (+)-6-epicastanospermine.