Back to Search
Start Over
Optimizing microdialysis for deep brain stimulation
- Source :
- Frontiers in bioscience (Elite edition). 8(2)
- Publication Year :
- 2015
-
Abstract
- Cerebral microdialysis is a chemical detection method capable of identifying and simultaneously sampling a wide range of substances in the micromilieu of the monitoring probe. The interstitial space of biological tissues and fluids is sampled through a thin fenestrated dialysis catheter inserted into the brain. The technique has been reported in patients with Parkinson's disease. However, the procedure is not widely used by neurosurgeons, possibly owing to unclear indications and poor effective benefits, mostly secondary to significant pitfalls. In spite of the feasibility of microdialysis in humans, many factors can affect the quality of the process. Possible pitfalls include improperly designed probe, probe insertion effects, ineffective perfusion rate, issues to optimize stabilization period, and insufficient volume sample. This article reviews those key technical features necessary for performing microdialysis in humans during deep brain stimulation for Parkinson's Disease.
- Subjects :
- Microdialysis
Deep brain stimulation
General Immunology and Microbiology
business.industry
medicine.medical_treatment
Deep Brain Stimulation
Parkinson Disease
Dialysis catheter
General Biochemistry, Genetics and Molecular Biology
Cerebral microdialysis
Perfusion rate
medicine
Humans
In patient
business
Biomedical engineering
Subjects
Details
- ISSN :
- 19450508
- Volume :
- 8
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Frontiers in bioscience (Elite edition)
- Accession number :
- edsair.doi.dedup.....f362ce3a99cc08e52c6665cc42b516fe