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Correlations between serum hepatitis B surface antigen and hepatitis B core antibody titers and liver fibrosis in treatment-naïve CHB patients
- Source :
- Journal of the Chinese Medical Association, Vol 81, Iss 12, Pp 1052-1059 (2018)
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- Background: Previous studies have revealed that quantitative hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (qAnti-HBc) levels can be used as predictors of treatment response in both interferon-α and nucleoside analogue therapies. Few data have been published regarding the relationship between quantitative HBsAg or Anti-HBc levels and liver fibrosis stages in patients with chronic hepatitis B (CHB). Methods: We conducted a cross-sectional study of treatment-naïve CHB patients. A total of 624 CHB patients were recruited. We assessed the serum HBsAg and qAnti-HBc levels, HBV DNA levels, HBV genotypes, BCP/PC mutations, histological fibrosis staging by Scheuer classification. Results: In HBeAg (+) patients, the S0-1 subjects had significantly higher serum HBsAg and lower qAnti-HBc levels than the S2-4 subjects (both p 0.05). Serum qAnti-HBc levels showed a moderate positive correlation with fibrosis scores (r = 0.383, p
- Subjects :
- Adult
Liver Cirrhosis
Male
medicine.medical_specialty
HBsAg
Hepatitis B virus
Liver fibrosis
Hepatitis b surface antigen
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Hepatitis B, Chronic
Fibrosis
Internal medicine
Medicine
Humans
Hepatitis B Antibodies
lcsh:R5-920
Hepatitis B Surface Antigens
Nucleoside analogue
business.industry
virus diseases
General Medicine
Middle Aged
medicine.disease
Hepatitis B Core Antigens
Hepatitis b core antibody
digestive system diseases
Titer
Cross-Sectional Studies
Logistic Models
HBeAg
Liver
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Female
business
lcsh:Medicine (General)
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 17264901
- Volume :
- 81
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of the Chinese Medical Association
- Accession number :
- edsair.doi.dedup.....f35ae6c73fddfaacf6fe687eda07b106