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Snake Venom Components: Tools and Cures to Target Cardiovascular Diseases

Snake Venom Components: Tools and Cures to Target Cardiovascular Diseases

Authors :
Mohamad Rima
Christian Legros
Jean-Marc Sabatier
Jacinthe Frangieh
César Mattei
Ziad Fajloun
Daniel Henrion
Lebanese University [Beirut] (LU)
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)
Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC)
Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Institut de neurophysiopathologie (INP)
Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
Leloup, Ludovic
Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC)
Source :
Molecules, Molecules, 2021, 26 (8), pp.2223. ⟨10.3390/molecules26082223⟩, Molecules, Vol 26, Iss 2223, p 2223 (2021), Molecules, MDPI, 2021, 26 (8), pp.2223. ⟨10.3390/molecules26082223⟩
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

International audience; Cardiovascular diseases (CVDs) are considered as a major cause of death worldwide. Therefore, identifying and developing therapeutic strategies to treat and reduce the prevalence of CVDs is a major medical challenge. Several drugs used for the treatment of CVDs, such as captopril, emerged from natural products, namely snake venoms. These venoms are complex mixtures of bioactive molecules, which, among other physiological networks, target the cardiovascular system, leading to them being considered in the development and design of new drugs. In this review, we describe some snake venom molecules targeting the cardiovascular system such as phospholipase A2 (PLA2), natriuretic peptides (NPs), bradykinin-potentiating peptides (BPPs), cysteine-rich secretory proteins (CRISPs), disintegrins, fibrinolytic enzymes, and three-finger toxins (3FTXs). In addition, their molecular targets, and mechanisms of action—vasorelaxation, inhibition of platelet aggregation, cardioprotective activities—are discussed. The dissection of their biological effects at the molecular scale give insights for the development of future snake venom-derived drugs.

Details

ISSN :
14203049
Volume :
26
Database :
OpenAIRE
Journal :
Molecules
Accession number :
edsair.doi.dedup.....f344e909029e68d7e752d795cefd3d0c
Full Text :
https://doi.org/10.3390/molecules26082223