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Correction: GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis
- Source :
- eLife, eLife, Vol 10 (2021)
- Publication Year :
- 2021
- Publisher :
- eLife Sciences Publications, Ltd, 2021.
-
Abstract
- Ribosome-associated quality control pathways respond to defects in translational elongation to recycle arrested ribosomes and degrade aberrant polypeptides and mRNAs. Loss of a tRNA gene leads to ribosomal pausing that is resolved by the translational GTPase GTPBP2, and in its absence causes neuron death. Here, we show that loss of the homologous protein GTPBP1 during tRNA deficiency in the mouse brain also leads to codon-specific ribosome pausing and neurodegeneration, suggesting that these non-redundant GTPases function in the same pathway to mitigate ribosome pausing. As observed in
- Subjects :
- QH301-705.5
Science
Biology
Mechanistic Target of Rapamycin Complex 1
Ribosome
General Biochemistry, Genetics and Molecular Biology
Mice
RNA, Transfer
Gene expression
Animals
Biology (General)
Monomeric GTP-Binding Proteins
Mice, Knockout
Neurons
Sirolimus
General Immunology and Microbiology
General Neuroscience
Correction
Neurodegenerative Diseases
General Medicine
Chromosomes and Gene Expression
Cell biology
Anti-Bacterial Agents
Neuronal homeostasis
Gene Expression Regulation
Medicine
Ribosomes
Neuroscience
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 2050084X
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- eLife
- Accession number :
- edsair.doi.dedup.....f33f9bb70f6518b9e351c533a23b8e47