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Regulation of ASK1 signaling by scaffold and adaptor proteins
- Source :
- Advances in Biological Regulation. 66:23-30
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The mitogen-activated protein kinase (MAPK) signaling pathway is a three-tiered kinase cascade where mitogen-activated protein kinase kinase kinases (MAP3Ks) lead to the activation of mitogen-activated protein kinase kinases (MAP2K), and ultimately MAPK proteins. MAPK signaling can promote a diverse set of biological outcomes, ranging from cell death to proliferation. There are multiple mechanisms which govern MAPK output, such as the duration and strength of the signal, cellular localization to upstream and downstream binding partners, pathway crosstalk and the binding to scaffold and adaptor molecules. This review will focus on scaffold and adaptor proteins that bind to and regulate apoptosis signal-regulating kinase 1 (ASK1), a MAP3K protein with a critical role in mediating stress response pathways.
- Subjects :
- 0301 basic medicine
Scaffold protein
Cancer Research
Mitogen-activated protein kinase kinase
MAP Kinase Kinase Kinase 5
MAP2K7
03 medical and health sciences
0302 clinical medicine
Genetics
Animals
Humans
ASK1
c-Raf
Molecular Biology
MAP kinase kinase kinase
Chemistry
Signal transducing adaptor protein
Cell biology
030104 developmental biology
Biochemistry
030220 oncology & carcinogenesis
Molecular Medicine
Cyclin-dependent kinase 9
Mitogen-Activated Protein Kinases
Protein Binding
Signal Transduction
Subjects
Details
- ISSN :
- 22124926
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Advances in Biological Regulation
- Accession number :
- edsair.doi.dedup.....f3385f4562512b5bb93193cebcb6f0cd