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A case of hyperprolactinaemia in a patient with metastatic melanoma
- Source :
- Melanoma research. 31(3)
- Publication Year :
- 2021
-
Abstract
- Ectopic prolactin production from a malignancy is infrequently reported. We report here a 60-year-old gentleman who presented with hyperprolactinaemia (9100 mIU/L) causing expressible galactorrhoea, decreased libido and fatigue thought to be due to ectopic prolactin secretion from a metastatic melanoma. Upon initiation of pembrolizumab, the patient's symptoms resolved and he became normoprolactinaemic. This corresponded with a partial response on radiological imaging. Although the core biopsy of the metastatic melanoma did not exhibit immunostaining for prolactin, we believe that only a subset of the tumour cells possesses prolactin-secreting capacity. This case illustrates the need to consider ectopic prolactin production for a solid malignant tumour as a rare cause of hyperprolactinaemia in patients with a normal pituitary MRI, in the absence of other causes.
- Subjects :
- 0301 basic medicine
Male
endocrine system
Cancer Research
Pathology
medicine.medical_specialty
Skin Neoplasms
Metastatic melanoma
Dermatology
Pembrolizumab
Malignancy
03 medical and health sciences
0302 clinical medicine
medicine
Humans
In patient
Melanoma
business.industry
Hyperprolactinaemia
Middle Aged
medicine.disease
Decreased Libido
Prolactin
Hyperprolactinemia
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
business
hormones, hormone substitutes, and hormone antagonists
Immunostaining
Subjects
Details
- ISSN :
- 14735636
- Volume :
- 31
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Melanoma research
- Accession number :
- edsair.doi.dedup.....f326ae259c8e6df4c8f66724cb7de801