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P-170 glycoprotein (P-170) is involved in the impairment of natural killer cell-mediated cytotoxicity in HIV+ patients
- Source :
- Immunology letters. 47(3)
- Publication Year :
- 1995
-
Abstract
- In the present study we analyze peripheral blood lymphocytes (PBL) from patients with human immunodeficiency virus (HIV) infection for both phenotypic expression and function of P-glycoprotein (P-170). This transmembrane efflux pump is known to be one of the mechanisms responsible for the multidrug resistance (MDR) in cancer therapy and it is also constitutively expressed in normal PBL. P-170 function, evaluated as Rhodamine 123 (Rh123) efflux in flow cytometry, was found to be significantly reduced in CD16+ natural killer (NK) cells from patients with HIV infection. Interestingly, this reduced efflux significantly correlates with the decreased NK cytotoxicity observed in HIV+ patients, as evaluated against the NK-specific K562 target cell line. These results support a possible role of the P-170-related pump in specific immunological lymphocyte function such as NK cell-mediated cytotoxicity.
- Subjects :
- Adult
Cytotoxicity, Immunologic
Male
Lymphocyte
Immunology
HIV Infections
CD16
Rhodamine 123
Flow cytometry
chemistry.chemical_compound
medicine
Immunology and Allergy
Humans
ATP Binding Cassette Transporter, Subfamily B, Member 1
Cytotoxicity
P-glycoprotein
Lymphokine-activated killer cell
biology
medicine.diagnostic_test
Receptors, IgG
Middle Aged
Flow Cytometry
CD56 Antigen
Killer Cells, Natural
medicine.anatomical_structure
chemistry
biology.protein
Female
Efflux
Subjects
Details
- ISSN :
- 01652478
- Volume :
- 47
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Immunology letters
- Accession number :
- edsair.doi.dedup.....f325849bcc27699bab9a94abd4b1e5b1