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Peptide deformylase inhibitors with activity against respiratory tract pathogens
- Source :
- Bioorganic & Medicinal Chemistry Letters. 14:59-62
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- A series of analogues of the peptide deformylase (PDF) inhibitor BB-3497 where the P3' amide bond was replaced with a ketone functionality is described. The in vitro antibacterial profiling of these compounds revealed that they demonstrate activity against pathogens associated with respiratory tract infections.
- Subjects :
- Clinical Biochemistry
Pharmaceutical Science
Microbial Sensitivity Tests
Biochemistry
Amidohydrolases
Microbiology
chemistry.chemical_compound
Peptide deformylase
Anti-Infective Agents
Drug Discovery
medicine
Peptide bond
Enzyme Inhibitors
Respiratory Tract Infections
Molecular Biology
Antibacterial agent
Hydroxamic acid
Respiratory tract infections
biology
Organic Chemistry
Biological activity
Haemophilus influenzae
Streptococcus pneumoniae
medicine.anatomical_structure
chemistry
Enzyme inhibitor
biology.protein
Molecular Medicine
Moraxella catarrhalis
Respiratory tract
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....f3124655adf092283e47a34533311a1e
- Full Text :
- https://doi.org/10.1016/j.bmcl.2003.10.013