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Intravenous Tranexamic Acid is Associated With a Clinically Significant Reduction in Blood Loss in Craniosynostosis Surgery
- Source :
- Journal of Craniofacial Surgery. 33:636-641
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- Blood loss is a potential cause of morbidity and mortality in craniosynostosis surgery. Recent reports have suggested that the use of tranexamic acid (TXA), an antifibrinolytic agent, mitigates this blood loss. A retrospective cohort study of patients undergoing craniosynostosis surgery at a tertiary craniofacial hospital in Sydney was undertaken. Primary outcomes were blood loss and transfusion requirements. Two groups were compared: those who received intravenous prophylactic TXA and those who underwent surgery without TXA. Statistical analysis was performed with Student t test and the Mann-Whitney U test for nonparametric results. We identified 206 patients who underwent craniosynostosis surgery over an 8 year period; 78 control patients and 128 patients that received TXA. Tranexamic acid was found to result in a weight-adjusted calculated blood loss mean difference of 9.6 ml/kg across all procedures (P = 0.0332 95% confidence interval 0.7734-18.4266). The actual blood loss reduction achieved with TXA was 6.7 ml/kg in spring cranioplasties, compared to 15.2 ml/kg in fronto-orbital remodeling procedures. There was a statistically and clinically significant reduction in postoperative transfusion incidence, with transfusions required in 27% of controls and 6% of TXA patients (P
- Subjects :
- medicine.medical_specialty
business.industry
Incidence (epidemiology)
Blood Loss, Surgical
Retrospective cohort study
General Medicine
medicine.disease
Antifibrinolytic Agents
Confidence interval
Surgery
Craniosynostosis
Craniosynostoses
Tranexamic Acid
Otorhinolaryngology
Antifibrinolytic agent
medicine
Number needed to treat
Humans
Craniofacial
business
Tranexamic acid
Retrospective Studies
medicine.drug
Subjects
Details
- ISSN :
- 15363732 and 10492275
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Journal of Craniofacial Surgery
- Accession number :
- edsair.doi.dedup.....f3092156c3626b180fc844f82bc9eb9a