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Huperzine A: A promising anticonvulsant, disease modifying, and memory enhancing treatment option in Alzheimer’s disease
- Source :
- Medical Hypotheses. 99:57-62
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Alzheimer's disease (AD) is the most frequent cause of dementia. Besides cognitive deterioration, patients with AD are prone to seizures - more than 20% of patients diagnosed with AD experience at least one unprovoked seizure and up to 7% have recurrent seizures. Although available antiepileptic drugs (AEDs) may suppress seizures in patients with AD, they may also worsen cognitive dysfunction and increase the risk of falls. On the basis of preclinical studies, we hypothesize that Huperzine A (HupA), a safe and potent acetylcholinesterase (AChE) inhibitor with potentially disease-modifying qualities in AD, may have a realistic role as an anticonvulsant in AD.
- Subjects :
- Risk
0301 basic medicine
medicine.medical_treatment
Interleukin-1beta
Disease
Pharmacology
Bioinformatics
Hippocampus
Animals, Genetically Modified
03 medical and health sciences
chemistry.chemical_compound
Alkaloids
0302 clinical medicine
Alzheimer Disease
Memory
Risk Factors
Seizures
medicine
Animals
Humans
Dementia
GABAergic Neurons
Phosphorylation
Huperzine A
Neurons
Amyloid beta-Peptides
Epilepsy
Tumor Necrosis Factor-alpha
Treatment options
Cognition
General Medicine
medicine.disease
Acetylcholinesterase
Disease Models, Animal
Neuroprotective Agents
030104 developmental biology
Anticonvulsant
Nicotinic agonist
chemistry
Disease Progression
Anticonvulsants
Cholinesterase Inhibitors
Cognition Disorders
Psychology
Sesquiterpenes
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 03069877
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Medical Hypotheses
- Accession number :
- edsair.doi.dedup.....f2fd42e335bd12f31b377e0b7a22c328