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A Dual‐Excitation Decoding Strategy Based on NIR Hybrid Nanocomposites for High‐Accuracy Thermal Sensing
- Source :
- Advanced Science, Vol 7, Iss 20, Pp n/a-n/a (2020), Advanced Science
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Optical thermal sensing holds great promise for disease theranostics. However, traditional ratiometric thermometry methods, in which intensity ratio of two nonoverlapping emissions is defined as the thermosensitive parameter, may have a limited accuracy in temperature read‐out due to the deleterious interference from wavelength‐ and temperature‐dependent photon attenuation in tissue. To overcome this limitation, a dual‐excitation decoding strategy based on NIR hybrid nanocomposites comprising self‐assembled quantum dots (QDs) and Nd3+ doped fluoride nanocrystals (NCs) is proposed for thermal sensing. Upon excitation at 808 nm, the intensity ratio of two emissions at identical wavelength (1057 nm) from QDs and NCs, respectively, is defined as the thermometric parameter R. By employing another 830 nm laser beam following the same optical path as 808 nm laser to exclusively excite QDs, the two overlapping emissions can be easily decoded. The acquired R proves to be inert to the detection depth in tissue, with a minimized temperature reading error of ≈2.3 °C at 35 °C (at a depth of ≈1.1 mm), while the traditional thermometry mode based on the nonoverlapping 1025 and 863 nm emissions may exhibit a large error of ≈43.0 °C. The insights provided by this work pave the way toward high‐accuracy deep‐tissue biosensing.<br />A dual‐excitation decoding strategy, which uses the intensity ratio of two overlapping NIR emissions from self‐assembled QDs and Nd3+ doped fluoride NCs in the hybrid nanocomposites, respectively, as the ratiometric thermometric parameter, is proposed for high‐accuracy thermal sensing in vivo.
- Subjects :
- Materials science
General Chemical Engineering
General Physics and Astronomy
Medicine (miscellaneous)
02 engineering and technology
010402 general chemistry
01 natural sciences
Biochemistry, Genetics and Molecular Biology (miscellaneous)
law.invention
Optical path
Interference (communication)
law
General Materials Science
lcsh:Science
photon attenuation
Nanocomposite
dual‐excitation decoding
Full Paper
business.industry
Doping
General Engineering
Full Papers
NIR hybrid nanocomposites
021001 nanoscience & nanotechnology
Laser
0104 chemical sciences
Wavelength
Quantum dot
Optoelectronics
lcsh:Q
0210 nano-technology
business
thermal sensing
Excitation
Subjects
Details
- Language :
- English
- ISSN :
- 21983844
- Volume :
- 7
- Issue :
- 20
- Database :
- OpenAIRE
- Journal :
- Advanced Science
- Accession number :
- edsair.doi.dedup.....f2f327122b450a643a5689f1cf9f5da5