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Gadolinium retention in gliomas and adjacent normal brain tissue: association with tumor contrast enhancement and linear/macrocyclic agents
- Source :
- Neuroradiology. 61:535-544
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- To quantitate gadolinium deposits in gliomas and adjacent normal brain specimens, and to evaluate their association with tumor contrast enhancement and the type of gadolinium-based contrast agent (GBCA) used. A total of 69 patients with primary glioma who underwent contrast-enhanced magnetic resonance imaging (MRI) prior to surgery were included in this retrospective study. Gadolinium was measured from histologically viable tumor, normal brain, and necrosis within the sample, when available, using inductively coupled plasma mass spectrometry (ICP-MS). Tumor contrast enhancement was categorized as none, minimal, or noticeable. Differences in gadolinium deposits by contrast enhancement and GBCA type were assessed. Seven patients received linear GBCA and 62 macrocyclic, respectively. At the time of surgery, gadolinium deposits were detected in 39 out of 69 (57%) tumor samples, 8 out of 13 (62%) normal brain, and 12 out of 14 (86%) necrotic specimens. Gadolinium was detected in both enhancing and non-enhancing tumors, but was greatest in gliomas with noticeable enhancement (p = 0.02). Administration of linear agents gadodiamide and gadopentetate dimeglumine resulted in significantly higher tumor gadolinium relative to macrocyclic gadoterate meglumine (p
- Subjects :
- Gadolinium DTPA
Male
Necrosis
Contrast enhancement
Gadolinium
Contrast Media
chemistry.chemical_element
Brain tissue
030218 nuclear medicine & medical imaging
03 medical and health sciences
Meglumine
0302 clinical medicine
Glioma
Organometallic Compounds
medicine
Humans
Radiology, Nuclear Medicine and imaging
In Situ Hybridization, Fluorescence
Retrospective Studies
Neuroradiology
medicine.diagnostic_test
Brain Neoplasms
business.industry
Gadodiamide
Brain
Magnetic resonance imaging
Middle Aged
medicine.disease
Immunohistochemistry
Magnetic Resonance Imaging
chemistry
Female
Neurology (clinical)
medicine.symptom
Cardiology and Cardiovascular Medicine
Nuclear medicine
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 14321920 and 00283940
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Neuroradiology
- Accession number :
- edsair.doi.dedup.....f2ef11f7213b1f492de2978c81ee1145