Back to Search
Start Over
Parenteral monofluorophosphate (MFP) is a more potent inducer of enamel fluorotic defects in neonatal hamster molars than sodium fluoride
- Source :
- Odontology, 102(2), 147-153. Springer Japan, Lyaruu, D M, Schoonderwoerd, M, Tio, D, Tse, C, Bervoets, T J, Denbesten, P & Bronckers, A L J J 2014, ' Parenteral monofluorophosphate (MFP) is a more potent inducer of enamel fluorotic defects in neonatal hamster molars than sodium fluoride ', Odontology, vol. 102, no. 2, pp. 147-153 . https://doi.org/10.1007/s10266-013-0119-0
- Publication Year :
- 2014
-
Abstract
- Supra-optimal intake of sodium fluoride (NaF) during early childhood results in formation of irreversible enamel defects. Monofluorophosphate (MFP) was considered as less toxic than NaF but equally cariostatic. We compared the potency of MFP and NaF to induce pre-eruptive sub-ameloblastic cysts and post-eruptive white spots and pits in developing hamster enamel. Hamster pups were injected subcutaneously with either NaF or MFP in equimolar doses of either 9 mg or 18 mg F/kg body weight. At 9 mg F/kg, MFP induced more but smaller sub-ameloblastic cysts with a collective cyst volume twice as large as that induced by NaF. Eight days after F injection, all F-injected groups had formed 4-6 white spots per molar, with an additional 2 pits per molar in the low MFP group. Twenty-eight days after injection, most white spots had turned into pits (5-6 per molar) and only the high MFP group still contained 2 white spots per molar. We conclude that parenterally applied MFP is more potent in inducing enamel defects than NaF. Most white spots formed turn into pits by functional use of the dentition. The higher potency of parenteral MFP may be associated with sustained elevated F levels in the enamel organ by enzymatic hydrolysis of MFP by alkaline phosphatase activity.
- Subjects :
- Molar
medicine.medical_specialty
Fluorosis, Dental
Hamster
Phosphates
Monofluorophosphate
Fluorides
chemistry.chemical_compound
stomatognathic system
Cricetinae
Internal medicine
Sodium fluoride
medicine
Animals
Infusions, Parenteral
Dental Enamel
General Dentistry
Enamel paint
Chemistry
Enamel organ
Alkaline Phosphatase
Endocrinology
Animals, Newborn
Biochemistry
visual_art
visual_art.visual_art_medium
Sodium Fluoride
Alkaline phosphatase
Fluoride
Subjects
Details
- Language :
- English
- ISSN :
- 16181247
- Volume :
- 102
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Odontology
- Accession number :
- edsair.doi.dedup.....f2dfd23b4a03196792c3aac6e07f2e5f