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Relationships between Anhydrous and Solvated Species of Dexketoprofen Trometamol: A Solid-State Point of View
- Source :
- Crystal growth & design (Online) 20 (2020): 226–236. doi:10.1021/acs.cgd.9b01030, info:cnr-pdr/source/autori:Rossi P.; Paoli P.; Chelazzi L.; Milazzo S.; Biagi D.; Valleri M.; Ienco A.; Valtancoli B.; Conti L./titolo:Relationships between Anhydrous and Solvated Species of Dexketoprofen Trometamol: A Solid-State Point of View/doi:10.1021%2Facs.cgd.9b01030/rivista:Crystal growth & design (Online)/anno:2020/pagina_da:226/pagina_a:236/intervallo_pagine:226–236/volume:20
- Publication Year :
- 2019
- Publisher :
- American Chemical Society (ACS), 2019.
-
Abstract
- The three different solid forms of dexktoprofen trometamol (DK-T_A, DK-T_B, and DK-T_2H2O) have been studied by using X-ray diffraction and calorimetric methods. In the molecular and crystal structure of DK-T_A, the thermodynamically stable form used in the tablets production process, all the potential H-bond donors and acceptors of each trometamol cation are involved in strong H-bonds which hold together the cations as well as the dexketoprofen/trometamol ionic pairs. The dihydrate species is quickly formed starting from DK-T_A apparently without the formation of an amorphous phase, and the process is fully reversible. In addition, the two solids have comparable crystal density (cell parameters and space group of the resulting hydrate were determined by X-ray powder diffraction). We speculate that the anhydrous and hydrate crystal architectures did not suffer upon the hydration/dehydration process and that the hydrate form belongs to the class of the channel hydrates and most probably is a planar hydrate. Finally, the unit cell parameters and space group were determined also for the metastable DK-T_B solid form.
- Subjects :
- Diffraction
X ray powder diffraction
010405 organic chemistry
Chemistry
Hydration
Ionic bonding
General Chemistry
Crystal structure
010402 general chemistry
Condensed Matter Physics
Dexketoprofen
01 natural sciences
0104 chemical sciences
Crystal
Crystallography
Positive ions
Anhydrous
medicine
Hydrates
General Materials Science
Hydrate
Powder diffraction
medicine.drug
Subjects
Details
- ISSN :
- 15287505 and 15287483
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Crystal Growth & Design
- Accession number :
- edsair.doi.dedup.....f2d4b8f8922359438f12a561759aeddc