Back to Search
Start Over
Antibacterial Activity of Pepducins, Allosterical Modulators of Formyl Peptide Receptor Signaling
- Source :
- Antimicrobial Agents and Chemotherapy. 58:2985-2988
- Publication Year :
- 2014
- Publisher :
- American Society for Microbiology, 2014.
-
Abstract
- Pepducins containing a fatty acid linked to an amino acid sequence derived from cytosolic parts of a G-protein-coupled receptor (GPCR) constitute a new group of lipopeptide tools in GPCR studies. Pepducins corresponding to the third intracellular loop of formyl peptide receptor 2 (FPR2) activate human neutrophils, and we show here that, in addition, these allosteric modulators of receptor activity also kill bacteria. The functional dualism of FPR2 pepducins could potentially be explored as a novel class of antibacterial drugs with immunomodulatory properties.
- Subjects :
- Pharmacology
Formyl peptide receptor
Neutrophils
Allosteric regulation
Lipopeptide
Biology
Receptors, Formyl Peptide
Anti-Bacterial Agents
Receptors, G-Protein-Coupled
Formyl peptide receptor 2
chemistry.chemical_compound
Infectious Diseases
Biochemistry
chemistry
Humans
Pharmacology (medical)
Biologic Response Modifiers
Signal transduction
Receptor
Peptide sequence
Signal Transduction
G protein-coupled receptor
Subjects
Details
- ISSN :
- 10986596 and 00664804
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Antimicrobial Agents and Chemotherapy
- Accession number :
- edsair.doi.dedup.....f2d2b06e1e10b18deaf99bb0703b7e80