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Tumor Microenvironment-Activable Manganese-Boosted Catalytic Immunotherapy Combined with PD-1 Checkpoint Blockade
- Source :
- ACS nano. 16(12)
- Publication Year :
- 2022
-
Abstract
- Immune checkpoint blockade (ICB) therapy has attracted widespread attention in cancer treatment. Due to the low immunogenicity and immune suppression state in the tumor microenvironment (TME), the therapeutic effects are only moderate. Herein, a TME-activable manganese-boosted catalytic immunotherapy is designed for synergism with ICB therapy to kill tumors efficiently. The tumor cell membrane (CM)-wrapping multienzyme-mimic manganese oxide (MnO
- Subjects :
- General Engineering
General Physics and Astronomy
General Materials Science
Subjects
Details
- ISSN :
- 1936086X
- Volume :
- 16
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- ACS nano
- Accession number :
- edsair.doi.dedup.....f2ce1e894714df57cc676725822635fe