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A Moderate-Fat Diet with One Avocado per Day Increases Plasma Antioxidants and Decreases the Oxidation of Small, Dense LDL in Adults with Overweight and Obesity: A Randomized Controlled Trial
- Source :
- The Journal of Nutrition
- Publication Year :
- 2019
- Publisher :
- Oxford University Press, 2019.
-
Abstract
- Background Avocados are a nutrient-dense source of MUFAs and are rich in antioxidants. Avocados have an additional LDL cholesterol (LDL-C) lowering effect beyond that observed when their MUFAs are substituted for SFAs, especially on small, dense LDL (sdLDL) particles, which are susceptible to in vivo oxidation and associated with increased risk of cardiovascular disease (CVD). Objectives We investigated whether a healthy diet with 1 avocado daily decreased the following secondary outcomes: circulating oxidized LDL (oxLDL) and related oxidative stress markers. Methods A randomized, crossover, controlled feeding trial was conducted with 45 men and women, aged 21–70 y, with overweight or obesity and elevated LDL-C (25th–90th percentile). Three cholesterol-lowering diets were provided (5 wk each) in random sequences: a lower-fat (LF) diet (24% calories from fat—7% SFAs, 11% MUFAs, 6% PUFAs) and 2 moderate-fat (MF) diets (34% calories from fat—6% SFAs, 17% MUFAs, 9% PUFAs): the avocado (AV) diet included 1 Hass avocado (∼136 g) per day, and the MF diet used high oleic acid oils to match the fatty acid profile of 1 avocado. A general linear mixed model was used to analyze the treatment effects. Results Compared with baseline, the AV diet significantly decreased circulating oxLDL (−7.0 U/L, –8.8%, P = 0.0004) and increased plasma lutein concentration (19.6 nmol/L, 68.7%, P
- Subjects :
- Male
Lutein
Calorie
Nutrition and Disease
Hass avocado
Medicine (miscellaneous)
Overweight
Antioxidants
chemistry.chemical_compound
small dense LDL
chemistry.chemical_classification
Nutrition and Dietetics
Cross-Over Studies
biology
lipoprotein
food and beverages
Vitamins
Middle Aged
CVD
Lipoproteins, LDL
lipids (amino acids, peptides, and proteins)
Female
medicine.symptom
Inflammation Mediators
Oxidation-Reduction
Polyunsaturated fatty acid
Adult
lipid transfer proteins
Young Adult
Animal science
lipid
medicine
Humans
MUFA
Obesity
RNA, Messenger
Aged
business.industry
Persea
Fatty acid
medicine.disease
biology.organism_classification
Dietary Fats
avocado
Oxidative Stress
chemistry
business
LDL oxidation
Biomarkers
Lipoprotein
Subjects
Details
- Language :
- English
- ISSN :
- 15416100 and 00223166
- Volume :
- 150
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The Journal of Nutrition
- Accession number :
- edsair.doi.dedup.....f2ca13a22635038c1750dffae3b43a4c