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Lower limb pulse rise time as a marker of peripheral arterial disease
- Publication Year :
- 2019
- Publisher :
- Institute of Electrical and Electronics Engineers, 2019.
-
Abstract
- Objective: The aim of the study was to show if pulse rise times (PRTs) extracted from photoplethysmographic (PPG) pulse waves (PWs) have an association with peripheral arterial disease (PAD) or its endovascular treatment, percutanoeus transluminal angioplasty (PTA) of the superficial femoral artery. Methods: Lower and upper limb PPG PWs were recorded and analyzed from 24 patients who suffered from PAD. The measurements were conducted before and after the treatment, and one month later by using transmission-mode PPG-probes placed in the index finger and second toe. Ankle-to-brachial pressure index and toe pressures were used as references in clinical patient measurements. PRTs, i.e., the time from the foot point to the peak point of the PW, were extracted from the PWs and compared bilaterally. The results from the PAD patients were also compared with 31 same-aged and 34 younger control subjects. Results: Statistically significant differences were found between the pretreatment PRTs of the treated limb of the PAD patients and the same-aged control subjects ( $p< 10^{-9}$ , Mann–Whitney U-test). The changes in the PRT of the treated lower limb were observed immediately after the PTA ( $p< 0.001$ , Student's t -test), and after one month ( $p< 0.0005$ ), whereas the PRTs of the non-treated lower limb and upper limb did not indicate changes between different examinations. Conclusion: Results show that a PRT greater than 240 ms indicates PAD-lesions in the lower limb. Significance: This proof-of-concept study suggests that the PRT could be an effective and easy-to-use indicator for PAD and monitoring the effectiveness of its treatment. acceptedVersion
- Subjects :
- Adult
pulse wave measurements
medicine.medical_specialty
Biolääketieteet - Biomedicine
Arterial disease
0206 medical engineering
Kirurgia, anestesiologia, tehohoito, radiologia - Surgery, anesthesiology, intensive care, radiology
Biomedical Engineering
pulse rise time
02 engineering and technology
Lower limb
Peripheral Arterial Disease
Young Adult
Heart Rate
peripheral arterial disease
Internal medicine
Photoplethysmogram
medicine
Humans
Photoplethysmography
Aged
Pulse (signal processing)
business.industry
Signal Processing, Computer-Assisted
217 Medical engineering
Index finger
Middle Aged
020601 biomedical engineering
Peripheral
body regions
medicine.anatomical_structure
Lower Extremity
Cardiology
Upper limb
photoplethysmography
atherosclerosis
Pulse rise time
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....f2c7c97818c0113bd9bdea232ab5d063