Back to Search
Start Over
Author Correction: Interleukin-6/STAT3 signalling regulates adipocyte induced epithelial-mesenchymal transition in breast cancer cells
- Source :
- Scientific Reports, Scientific Reports, Vol 10, Iss 1, Pp 1-3 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group UK, 2020.
-
Abstract
- The tumour microenvironment is a key regulators of tumour progression through the secretion of growth factors that activate epithelial-mesenchymal transition (EMT). Induction of EMT is a key step for transition from a benign state to a metastatic tumour. Adipose tissue forms a bulk portion of the breast cancer microenvironment, emerging evidence indicates the potential for adipocytes to influence tumour progression through the secretion of adipokines that can induce EMT. The molecular mechanisms underlying how adipocytes enhance breast cancer progression is largely unknown. We hypothesized that paracrine signalling by adipocytes can activate EMT and results in increased migration and invasion characteristics of breast cancer cells. We found that IL-6 secreted by adipocytes induce EMT in breast cancer cells. The effect of IL-6 expression on EMT is mediated through activation of the signal transducer and activated of transcription 3 (STAT3). Blocking of IL-6 signalling in breast cancer cells and adipocytes, decreased proliferation, migration and invasion capabilities and altered the expression of genes regulating EMT. Together, our results suggest that matured human adipocytes can enhance the aggressive behaviour of breast cancer cells and induce an EMT-phenotype through paracrine IL-6/STAT3 signalling.
- Subjects :
- STAT3 Transcription Factor
Epithelial-Mesenchymal Transition
lcsh:Medicine
Breast Neoplasms
chemistry.chemical_compound
Cell Movement
Adipocyte
Cell Line, Tumor
Paracrine Communication
Adipocytes
Tumor Microenvironment
Humans
Neoplasm Invasiveness
Epithelial–mesenchymal transition
STAT3
Interleukin 6
lcsh:Science
Author Correction
Cell Proliferation
Multidisciplinary
biology
Chemistry
Interleukin-6
lcsh:R
Gene Expression Regulation, Neoplastic
Signalling
biology.protein
Cancer research
lcsh:Q
Female
Breast cancer cells
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....f2c37fb8d8b776a700aff977fb7547f8