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Baseline 10-Year Cardiovascular Risk Scores Predict Cognitive Function in Older Persons, and Particularly Women, Living With Human Immunodeficiency Virus Infection
- Source :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 71, iss 12, Clin Infect Dis
- Publication Year :
- 2020
- Publisher :
- eScholarship, University of California, 2020.
-
Abstract
- BackgroundCardiovascular disease (CVD) and associated comorbidities increase the risk of cognitive impairment in persons living with human immunodeficiency virus (PLWH). Given the potential composite effect of multiple cardiovascular risk factors on cognition, we examined the ability of the Atherosclerotic Cardiovascular Disease (ASCVD) risk score and the Framingham Heart Study Global CVD risk score (FRS) to predict future cognitive function in older PLWH.MethodsWe constructed linear regression models evaluating the association between baseline 10-year cardiovascular risk scores and cognitive function (measured by a summary z-score, the NPZ-4) at a year 4 follow-up visit.ResultsAmong 988 participants (mean age, 52 years; 20% women), mean 10-year ASCVD risk score at entry into the cohort was 6.8% (standard deviation [SD], 7.1%) and FRS was 13.1% (SD, 10.7%). In models adjusted only for cognitive function at entry, the ASCVD risk score significantly predicted year 4 NPZ-4 in the entire cohort and after stratification by sex (for every 1% higher ASCVD risk, year 4 NPZ-4 was lower by 0.84 [SD, 0.28] overall, P = .003; lower by 2.17 [SD, 0.67] in women, P = .001; lower by 0.78 [SD, 0.32] in men, P = .016). A similar relationship was observed between FRS and year 4 NPZ-4. In multivariable models, higher 10-year ASCVD risk and FRS predicted lower NPZ-4 in women.ConclusionsBaseline 10-year ASCVD risk and FRS predicted future cognitive function in older PLWH with well-controlled infection. Cardiovascular risk scores may help to identify PLWH, especially women, who are at risk for worse cognition over time.
- Subjects :
- Male
Aging
Human immunodeficiency virus (HIV)
HIV Infections
Disease
030204 cardiovascular system & hematology
medicine.disease_cause
Cardiovascular
Medical and Health Sciences
risk prediction
0302 clinical medicine
Framingham Heart Study
Cognition
Risk Factors
80 and over
Cognitive impairment
Aged, 80 and over
Framingham Risk Score
Middle Aged
Biological Sciences
CVD
Infectious Diseases
Heart Disease
Cardiovascular Diseases
Cohort
Female
Microbiology (medical)
cardiovascular risk
medicine.medical_specialty
Cardiovascular risk factors
Risk Assessment
Microbiology
03 medical and health sciences
Clinical Research
Internal medicine
Behavioral and Social Science
medicine
Humans
cognitive function
Aged
business.industry
Prevention
HIV
HIV infection
Major Articles and Commentaries
Good Health and Well Being
Heart Disease Risk Factors
business
030217 neurology & neurosurgery
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 71, iss 12, Clin Infect Dis
- Accession number :
- edsair.doi.dedup.....f2b44806eeb943f1035cb4618d6e89aa