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Serum P-glycoprotein level: a potential biomarker of DMARD failure in patients with rheumatoid arthritis
- Source :
- Inflammopharmacology. 26:1375-1381
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- To evaluate the utility of elevated serum P-glycoprotein (P-gp) as a risk marker of therapeutic response failure in rheumatoid arthritis (RA) patients treated with disease-modifying antirheumatic drugs (DMARDs). A cross-sectional study was conducted in 151 RA patients. Patients were classified into two groups according to the response achieved in terms of the disease activity score (DAS)28 after ≥ 6 months: (1) patients with a therapeutic response to DMARDs, with DAS28
- Subjects :
- musculoskeletal diseases
0301 basic medicine
Allergy
medicine.medical_specialty
Immunology
Drug resistance
Logistic regression
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Pharmacology (medical)
skin and connective tissue diseases
Prospective cohort study
P-glycoprotein
030203 arthritis & rheumatology
Pharmacology
biology
business.industry
Confounding
medicine.disease
Rheumatology
030104 developmental biology
Rheumatoid arthritis
biology.protein
business
Subjects
Details
- ISSN :
- 15685608 and 09254692
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Inflammopharmacology
- Accession number :
- edsair.doi.dedup.....f2ae99e154883840244bb700d585c33a
- Full Text :
- https://doi.org/10.1007/s10787-018-0529-2