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Serum P-glycoprotein level: a potential biomarker of DMARD failure in patients with rheumatoid arthritis

Authors :
Jorge I. Gamez-Nava
Esther N Sanchez-Rodriguez
José Francisco Muñoz-Valle
Sergio Ramón Gutiérrez-Ureña
José Clemente Vásquez-Jiménez
Sergio Cerpa-Cruz
N. A. Rodriguez-Jimenez
Erika Anita Aguilar-Chavez
M. L. Vazquez-Villegas
Laura Gonzalez-Lopez
Edsaul Emilio Perez-Guerrero
Ana Miriam Saldaña-Cruz
N. S. Fajardo-Robledo
Ernesto Germán Cardona-Muñoz
M. Ramirez-Villafaña
Source :
Inflammopharmacology. 26:1375-1381
Publication Year :
2018
Publisher :
Springer Science and Business Media LLC, 2018.

Abstract

To evaluate the utility of elevated serum P-glycoprotein (P-gp) as a risk marker of therapeutic response failure in rheumatoid arthritis (RA) patients treated with disease-modifying antirheumatic drugs (DMARDs). A cross-sectional study was conducted in 151 RA patients. Patients were classified into two groups according to the response achieved in terms of the disease activity score (DAS)28 after ≥ 6 months: (1) patients with a therapeutic response to DMARDs, with DAS28

Details

ISSN :
15685608 and 09254692
Volume :
26
Database :
OpenAIRE
Journal :
Inflammopharmacology
Accession number :
edsair.doi.dedup.....f2ae99e154883840244bb700d585c33a
Full Text :
https://doi.org/10.1007/s10787-018-0529-2