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Real‐world clinical outcomes of sofosbuvir and velpatasvir treatment in HCV genotype 1‐ and 2‐infected patients with decompensated cirrhosis: A nationwide multicenter study by the Japanese Red Cross Liver Study Group
- Source :
- Journal of Medical Virology. 93:6247-6256
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- The real-world virological efficacy and safety of interferon-free direct-acting antiviral (DAA) therapy with sofosbuvir (SOF) and velpatasvir (VEL) were assessed in hepatitis C virus (HCV) genotype 1- and 2-infected patients with decompensated cirrhosis. A total of 65 patients with HCV-related decompensated cirrhosis (Child-Pugh score of 7 points or more) who were treated with the SOF/VEL regimen were enrolled. The sustained virological response (SVR) rate and safety profile were analyzed. SVR was defined as undetectable serum HCV RNA at 12 weeks after the end of treatment (SVR12). The percentages of patients with undetectable HCV RNA at 4, 8, and 12 weeks after the start of therapy were 81.2% (95% confidence interval [CI], 69.5-89.9) (52/64), 98.4% (95% CI, 91.2-100.0) (60/61), and 98.5% (95% CI, 91.7-100.0) (64/65), respectively. The overall SVR rate was 92.3% (95% CI, 83.0-97.5) (60/65). Albumin-bilirubin (ALBI) scores decreased during and after treatment (p
- Subjects :
- Liver Cirrhosis
Male
medicine.medical_specialty
Genotype
Sustained Virologic Response
Sofosbuvir
Hepatitis C virus
Hepacivirus
medicine.disease_cause
Antiviral Agents
Heterocyclic Compounds, 4 or More Rings
Gastroenterology
Japan
Virology
Internal medicine
Ascites
medicine
Humans
Adverse effect
Aged
business.industry
virus diseases
Hepatitis C, Chronic
Middle Aged
Hepatology
medicine.disease
digestive system diseases
Confidence interval
Drug Combinations
Regimen
Infectious Diseases
Hepatocellular carcinoma
Female
Carbamates
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 10969071 and 01466615
- Volume :
- 93
- Database :
- OpenAIRE
- Journal :
- Journal of Medical Virology
- Accession number :
- edsair.doi.dedup.....f2a82460d15c40a60aa82a873555a688
- Full Text :
- https://doi.org/10.1002/jmv.27157