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Pyridinic analog of the natural product (-)-spectaline as potential adjuvant for the treatment of central nervous system disorders
- Source :
- Bioorganicmedicinal chemistry letters. 25(10)
- Publication Year :
- 2014
-
Abstract
- Previously we designed a series of pyridinic anticholinesterasic compounds based on molecular hybridization between tacrine and the natural piperidine alkaloid (-)-3-O-acetylspectaline isolated from Senna spectabilis. Based on the information that the cholinergic system has an important role in the treatment of schizophrenia and depression, we herein report the evaluation of a series of pyridinic compounds in animal models for antipsychotic and antidepressant-like activities. Compound 2 decreased the immobility time of mice in the forced swimming test (5 and 10mg/kg p.o.) and prevented the climbing behavior induced by apomorphine (10mg/kg, p.o.), without impairing animals locomotor activity.
- Subjects :
- Pyridines
medicine.medical_treatment
Clinical Biochemistry
Central nervous system
Pharmaceutical Science
Pharmacology
Biochemistry
chemistry.chemical_compound
Mice
Piperidines
Central Nervous System Diseases
Drug Discovery
Senna spectabilis
medicine
Animals
Antipsychotic
Molecular Biology
Natural product
biology
Behavior, Animal
Chemistry
Alkaloid
Organic Chemistry
biology.organism_classification
Antidepressive Agents
Apomorphine
Disease Models, Animal
medicine.anatomical_structure
Tacrine
Schizophrenia
Molecular Medicine
Behavioural despair test
medicine.drug
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 25
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....f2a7d9d8cfb244d4b2fcf079ab14c8e1